Depression and Temporal Lobe Epilepsy: Expression Pattern of Calbindin Immunoreactivity in Hippocampal Dentate Gyrus of Patients Who Underwent Epilepsy Surgery with and without Comorbid Depression

Purpose. Changes in calbindin (CB) expression have been reported in patients with temporal lobe epilepsy (TLE) with controversial implications on hippocampal functions. The aim of this study was to determine the CB immunoreactivity in hippocampal dentate gyrus of patients who underwent epilepsy surg...

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Bibliographic Details
Published in:Behavioural neurology 2019-01, Vol.2019 (2019), p.1-12
Main Authors: Kochen, Silvia, Oddo, Silvia, Nuñez, Claudio, Lima, Mónica Fernandez, Scévola, Laura, Solis, Patricia, Konopka, Hector, D’Alessio, Luciana, Seoane, Eduardo
Format: Article
Language:English
Subjects:
Adult
Calbindins - genetics
Calbindins - immunology
Comorbidity
Dentate Gyrus - immunology
Depression - genetics
Depression - physiopathology
Drug resistance
Electroencephalography
Endocrinology
Epilepsy
Epilepsy - complications
Epilepsy - surgery
Epilepsy, Temporal Lobe - complications
Epilepsy, Temporal Lobe - genetics
Epilepsy, Temporal Lobe - surgery
Female
Gene expression
Gene Expression Profiling - methods
Hippocampus - metabolism
Humans
Localization
Magnetic Resonance Imaging
Male
Memory
Memory Disorders - complications
Mental depression
Middle Aged
Neurogenesis
Neurons - metabolism
Neurosciences
NMR
Nuclear magnetic resonance
Patients
Pilot Projects
Surgery
Temporal Lobe - metabolism
Temporal lobe epilepsy
Transcriptome - genetics
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Summary:Purpose. Changes in calbindin (CB) expression have been reported in patients with temporal lobe epilepsy (TLE) with controversial implications on hippocampal functions. The aim of this study was to determine the CB immunoreactivity in hippocampal dentate gyrus of patients who underwent epilepsy surgery for drug-resistant TLE with and without comorbid depression and/or memory deficits. Methods. Selected hippocampal samples from patients with TLE who underwent epilepsy surgery were included. Clinical and complementary assessment: EEG, video-EEG, MRI, psychiatric assessment (structured clinical interview, DSM-IV), and memory assessment (Rey auditory verbal learning test, RAVLT; Rey-Osterrieth complex figure test, RCFT), were determined before surgery. Hippocampal sections were processed using immunoperoxidase with the anti-calbindin antibody. The semiquantitative analysis of CB immunoreactivity was determined in dentate gyrus by computerized image analysis (ImageJ). Results. Hippocampal sections of patients with TLE and HS (n=24) and postmortem controls (n=5) were included. A significant reduction of CB+ cells was found in patients with TLE (p
ISSN:0953-4180
1875-8584
DOI:10.1155/2019/7396793