Association of preoperative seizures with tumor metabolites quantified by magnetic resonance spectroscopy in gliomas

Seizures are common in patients with gliomas; however, the mechanisms of epileptogenesis in gliomas have not been fully understood. This study hypothesized that analyzing quantified metabolites using magnetic resonance spectroscopy (MRS) might provide novel insights to better understand the epilepto...

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Bibliographic Details
Published in:Scientific reports 2021-04, Vol.11 (1), p.7927-7927, Article 7927
Main Authors: Nakae, Shunsuke, Kumon, Masanobu, Murayama, Kazuhiro, Ohba, Shigeo, Sasaki, Hikaru, Inamasu, Joji, Kuwahara, Kiyonori, Yamada, Seiji, Abe, Masato, Hirose, Yuichi
Format: Article
Language:English
Subjects:
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631/67
Epilepsy
Glioma
Histology
Humanities and Social Sciences
Isocitrate dehydrogenase
Magnetic resonance spectroscopy
Metabolites
multidisciplinary
Mutants
Patients
Science
Science (multidisciplinary)
Seizures
Spectroscopy
Spectrum analysis
Tumors
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Summary:Seizures are common in patients with gliomas; however, the mechanisms of epileptogenesis in gliomas have not been fully understood. This study hypothesized that analyzing quantified metabolites using magnetic resonance spectroscopy (MRS) might provide novel insights to better understand the epileptogenesis in gliomas, and specific metabolites might be indicators of preoperative seizures in gliomas. We retrospectively investigated patient information (gender, age at diagnosis of tumor, their survival time) and tumor information (location, histology, genetic features, and metabolites according to MRS) in patients with gliomas. The data were correlated with the incidence of seizure and analyzed statistically. Of 146 adult supratentorial gliomas, isocitrate dehydrogenase ( IDH ) mutant tumors significantly indicated higher incidence of preoperative seizures than IDH wild-type gliomas. However, MRS study indicated that glutamate concentration in IDH wild-type gliomas was higher than that in IDH mutant gliomas. Glutamate was not associated with high frequency of preoperative seizures in patients with gliomas. Instead, increased total N -acetyl- l -aspartate (tNAA) was significantly associated with them. Moreover, multivariable analysis indicated that increased level of tNAA was an independent predictor of preoperative seizures. According to MRS analysis, tNAA, rather than glutamate, might be a useful to detect preoperative seizures in patient with supratentorial gliomas.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-86487-6