Frailty and Cardiovascular Health

The incidence of frailty and cardiovascular disease (CVD) increases as the population ages. There is a bidirectional relationship between frailty and CVD, and both conditions share several risk factors and underlying biological mechanisms. Frailty has been established as an independent prognostic ma...

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Bibliographic Details
Published in:Journal of the American Heart Association 2024-08, Vol.13 (15), p.e031736
Main Authors: James, Kirstyn, Jamil, Yasser, Kumar, Manish, Kwak, Min J, Nanna, Michael G, Qazi, Saadia, Troy, Aaron L, Butt, Jawad H, Damluji, Abdulla A, Forman, Daniel E, Orkaby, Ariela R
Format: Article
Language:English
Subjects:
Aged
aging
cardiovascular diseases
Cardiovascular Diseases - epidemiology
Cardiovascular Diseases - prevention & control
cardiovascular interventions
Frail Elderly
frailty
Frailty - complications
Frailty - diagnosis
Frailty - epidemiology
Geriatric Assessment - methods
geriatric syndromes
Heart Disease Risk Factors
Humans
Incidence
primary prevention
Prognosis
Risk Assessment
Risk Factors
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Summary:The incidence of frailty and cardiovascular disease (CVD) increases as the population ages. There is a bidirectional relationship between frailty and CVD, and both conditions share several risk factors and underlying biological mechanisms. Frailty has been established as an independent prognostic marker in patients with CVD. Moreover, its presence significantly influences both primary and secondary prevention strategies for adults with CVD while also posing a barrier to the inclusion of these patients in pivotal clinical trials and advanced cardiac interventions. This review discusses the current knowledge base on the relationship between frailty and CVD, how managing CVD risk factors can modify frailty, the influence of frailty on CVD management, and future directions for frailty detection and modification in patients with CVD.
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.123.031736