Microenvironmental regulation of tumor-associated neutrophils in malignant glioma: from mechanism to therapy

Glioma is the most common primary intracranial tumor in adults, with high incidence, recurrence, and mortality rates. Tumor-associated neutrophils (TANs) are essential components of the tumor microenvironment (TME) in glioma and play a crucial role in glioma cell proliferation, invasion and proneura...

Full description

Saved in:
Bibliographic Details
Published in:Journal of neuroinflammation 2024-09, Vol.21 (1), p.226-19
Main Authors: Wen, Jiayi, Liu, Dan, Zhu, Hongtao, Shu, Kai
Format: Article
Language:English
Subjects:
Animals
Brain Neoplasms - immunology
Brain Neoplasms - pathology
Brain Neoplasms - therapy
Cancer
Care and treatment
Glioma - immunology
Glioma - pathology
Glioma - therapy
Gliomas
Health aspects
Humans
Immunotherapy
Malignant glioma
Neutrophils
Neutrophils - immunology
Neutrophils - pathology
Oncology, Experimental
Physiological aspects
Review
Targeted therapy
Tumor microenvironment
Tumor Microenvironment - immunology
Tumor Microenvironment - physiology
Tumor-associated neutrophils
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 19
container_issue 1
container_start_page 226
container_title Journal of neuroinflammation
container_volume 21
creator Wen, Jiayi
Liu, Dan
Zhu, Hongtao
Shu, Kai
description Glioma is the most common primary intracranial tumor in adults, with high incidence, recurrence, and mortality rates. Tumor-associated neutrophils (TANs) are essential components of the tumor microenvironment (TME) in glioma and play a crucial role in glioma cell proliferation, invasion and proneural-mesenchymal transition. Besides the interactions between TANs and tumor cells, the multi-dimensional crosstalk between TANs and other components within TME have been reported to participate in glioma progression. More importantly, several therapies targeting TANs have been developed and relevant preclinical and clinical studies have been conducted in cancer therapy. In this review, we introduce the origin of TANs and the functions of TANs in malignant behaviors of glioma, highlighting the microenvironmental regulation of TANs. Moreover, we focus on summarizing the TANs-targeted methods in cancer therapy, aiming to provide insights into the mechanisms and therapeutic opportunities of TANs in the malignant glioma microenvironment.
doi_str_mv 10.1186/s12974-024-03222-4
format article
fullrecord <record><control><sourceid>gale_doaj_</sourceid><recordid>TN_cdi_doaj_primary_oai_doaj_org_article_219ce4aacf094f9393d8995a74acf596</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><galeid>A808910934</galeid><doaj_id>oai_doaj_org_article_219ce4aacf094f9393d8995a74acf596</doaj_id><sourcerecordid>A808910934</sourcerecordid><originalsourceid>FETCH-LOGICAL-d374t-8a329c9c3e90d7e3c29756b19c0eec806d1c82210fd8956229eae91edcfc32d23</originalsourceid><addsrcrecordid>eNptkltrFTEUhQdR7PUP-CABX3yZNre5xBcpRWuh4os-h93MnjkpuRyTTKH_vtFTpQdKCAkrK1_22qRp3jF6xtjYn2fG1SBbyusUnPNWvmoO2SB5y6mSr5_tD5qjnO9odXU9f9scCMXHjg_9YeO-W5MihnubYvAYCjiScFkdFBsDiTMpq4-phZyjsVBwIgHXkuJ2Y10mNhAPzi4BQiGLs9HDJzKn6IlHs4FgsyclkrLBBNuHk-bNDC7j6dN63Pz6-uXn5bf25sfV9eXFTTuJQZZ2BMGVUUagotOAwtSYXX_LlKGIZqT9xMzIOaPzNKoaiCsEVAwnMxvBJy6Om-sdd4pwp7fJekgPOoLVf4WYFg2pWONQ80pFCWDm2qZZCSUqU3UwyCp1qq-szzvWdr319YnaogRuD7p_EuxGL_FeMyZpP3asEj4-EVL8vWIu2tts0DkIGNesBaM9ld3QqWr9sLMuUGuzYY4Vaf7Y9cVIR8WoErK6zl5w1TGhtyYGnG3V9y68f57hf_H_voF4BKoStt4</addsrcrecordid><sourcetype>Open Website</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>3106045759</pqid></control><display><type>article</type><title>Microenvironmental regulation of tumor-associated neutrophils in malignant glioma: from mechanism to therapy</title><source>Open Access: PubMed Central</source><source>Publicly Available Content (ProQuest)</source><creator>Wen, Jiayi ; Liu, Dan ; Zhu, Hongtao ; Shu, Kai</creator><creatorcontrib>Wen, Jiayi ; Liu, Dan ; Zhu, Hongtao ; Shu, Kai</creatorcontrib><description>Glioma is the most common primary intracranial tumor in adults, with high incidence, recurrence, and mortality rates. Tumor-associated neutrophils (TANs) are essential components of the tumor microenvironment (TME) in glioma and play a crucial role in glioma cell proliferation, invasion and proneural-mesenchymal transition. Besides the interactions between TANs and tumor cells, the multi-dimensional crosstalk between TANs and other components within TME have been reported to participate in glioma progression. More importantly, several therapies targeting TANs have been developed and relevant preclinical and clinical studies have been conducted in cancer therapy. In this review, we introduce the origin of TANs and the functions of TANs in malignant behaviors of glioma, highlighting the microenvironmental regulation of TANs. Moreover, we focus on summarizing the TANs-targeted methods in cancer therapy, aiming to provide insights into the mechanisms and therapeutic opportunities of TANs in the malignant glioma microenvironment.</description><identifier>ISSN: 1742-2094</identifier><identifier>EISSN: 1742-2094</identifier><identifier>DOI: 10.1186/s12974-024-03222-4</identifier><identifier>PMID: 39285276</identifier><language>eng</language><publisher>England: BioMed Central Ltd</publisher><subject>Animals ; Brain Neoplasms - immunology ; Brain Neoplasms - pathology ; Brain Neoplasms - therapy ; Cancer ; Care and treatment ; Glioma - immunology ; Glioma - pathology ; Glioma - therapy ; Gliomas ; Health aspects ; Humans ; Immunotherapy ; Malignant glioma ; Neutrophils ; Neutrophils - immunology ; Neutrophils - pathology ; Oncology, Experimental ; Physiological aspects ; Review ; Targeted therapy ; Tumor microenvironment ; Tumor Microenvironment - immunology ; Tumor Microenvironment - physiology ; Tumor-associated neutrophils</subject><ispartof>Journal of neuroinflammation, 2024-09, Vol.21 (1), p.226-19</ispartof><rights>2024. The Author(s).</rights><rights>COPYRIGHT 2024 BioMed Central Ltd.</rights><rights>The Author(s) 2024 2024</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406851/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406851/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27923,27924,37012,53790,53792</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/39285276$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wen, Jiayi</creatorcontrib><creatorcontrib>Liu, Dan</creatorcontrib><creatorcontrib>Zhu, Hongtao</creatorcontrib><creatorcontrib>Shu, Kai</creatorcontrib><title>Microenvironmental regulation of tumor-associated neutrophils in malignant glioma: from mechanism to therapy</title><title>Journal of neuroinflammation</title><addtitle>J Neuroinflammation</addtitle><description>Glioma is the most common primary intracranial tumor in adults, with high incidence, recurrence, and mortality rates. Tumor-associated neutrophils (TANs) are essential components of the tumor microenvironment (TME) in glioma and play a crucial role in glioma cell proliferation, invasion and proneural-mesenchymal transition. Besides the interactions between TANs and tumor cells, the multi-dimensional crosstalk between TANs and other components within TME have been reported to participate in glioma progression. More importantly, several therapies targeting TANs have been developed and relevant preclinical and clinical studies have been conducted in cancer therapy. In this review, we introduce the origin of TANs and the functions of TANs in malignant behaviors of glioma, highlighting the microenvironmental regulation of TANs. Moreover, we focus on summarizing the TANs-targeted methods in cancer therapy, aiming to provide insights into the mechanisms and therapeutic opportunities of TANs in the malignant glioma microenvironment.</description><subject>Animals</subject><subject>Brain Neoplasms - immunology</subject><subject>Brain Neoplasms - pathology</subject><subject>Brain Neoplasms - therapy</subject><subject>Cancer</subject><subject>Care and treatment</subject><subject>Glioma - immunology</subject><subject>Glioma - pathology</subject><subject>Glioma - therapy</subject><subject>Gliomas</subject><subject>Health aspects</subject><subject>Humans</subject><subject>Immunotherapy</subject><subject>Malignant glioma</subject><subject>Neutrophils</subject><subject>Neutrophils - immunology</subject><subject>Neutrophils - pathology</subject><subject>Oncology, Experimental</subject><subject>Physiological aspects</subject><subject>Review</subject><subject>Targeted therapy</subject><subject>Tumor microenvironment</subject><subject>Tumor Microenvironment - immunology</subject><subject>Tumor Microenvironment - physiology</subject><subject>Tumor-associated neutrophils</subject><issn>1742-2094</issn><issn>1742-2094</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNptkltrFTEUhQdR7PUP-CABX3yZNre5xBcpRWuh4os-h93MnjkpuRyTTKH_vtFTpQdKCAkrK1_22qRp3jF6xtjYn2fG1SBbyusUnPNWvmoO2SB5y6mSr5_tD5qjnO9odXU9f9scCMXHjg_9YeO-W5MihnubYvAYCjiScFkdFBsDiTMpq4-phZyjsVBwIgHXkuJ2Y10mNhAPzi4BQiGLs9HDJzKn6IlHs4FgsyclkrLBBNuHk-bNDC7j6dN63Pz6-uXn5bf25sfV9eXFTTuJQZZ2BMGVUUagotOAwtSYXX_LlKGIZqT9xMzIOaPzNKoaiCsEVAwnMxvBJy6Om-sdd4pwp7fJekgPOoLVf4WYFg2pWONQ80pFCWDm2qZZCSUqU3UwyCp1qq-szzvWdr319YnaogRuD7p_EuxGL_FeMyZpP3asEj4-EVL8vWIu2tts0DkIGNesBaM9ld3QqWr9sLMuUGuzYY4Vaf7Y9cVIR8WoErK6zl5w1TGhtyYGnG3V9y68f57hf_H_voF4BKoStt4</recordid><startdate>20240916</startdate><enddate>20240916</enddate><creator>Wen, Jiayi</creator><creator>Liu, Dan</creator><creator>Zhu, Hongtao</creator><creator>Shu, Kai</creator><general>BioMed Central Ltd</general><general>BioMed Central</general><general>BMC</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>5PM</scope><scope>DOA</scope></search><sort><creationdate>20240916</creationdate><title>Microenvironmental regulation of tumor-associated neutrophils in malignant glioma: from mechanism to therapy</title><author>Wen, Jiayi ; Liu, Dan ; Zhu, Hongtao ; Shu, Kai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-d374t-8a329c9c3e90d7e3c29756b19c0eec806d1c82210fd8956229eae91edcfc32d23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Animals</topic><topic>Brain Neoplasms - immunology</topic><topic>Brain Neoplasms - pathology</topic><topic>Brain Neoplasms - therapy</topic><topic>Cancer</topic><topic>Care and treatment</topic><topic>Glioma - immunology</topic><topic>Glioma - pathology</topic><topic>Glioma - therapy</topic><topic>Gliomas</topic><topic>Health aspects</topic><topic>Humans</topic><topic>Immunotherapy</topic><topic>Malignant glioma</topic><topic>Neutrophils</topic><topic>Neutrophils - immunology</topic><topic>Neutrophils - pathology</topic><topic>Oncology, Experimental</topic><topic>Physiological aspects</topic><topic>Review</topic><topic>Targeted therapy</topic><topic>Tumor microenvironment</topic><topic>Tumor Microenvironment - immunology</topic><topic>Tumor Microenvironment - physiology</topic><topic>Tumor-associated neutrophils</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wen, Jiayi</creatorcontrib><creatorcontrib>Liu, Dan</creatorcontrib><creatorcontrib>Zhu, Hongtao</creatorcontrib><creatorcontrib>Shu, Kai</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>Open Access: DOAJ - Directory of Open Access Journals</collection><jtitle>Journal of neuroinflammation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wen, Jiayi</au><au>Liu, Dan</au><au>Zhu, Hongtao</au><au>Shu, Kai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Microenvironmental regulation of tumor-associated neutrophils in malignant glioma: from mechanism to therapy</atitle><jtitle>Journal of neuroinflammation</jtitle><addtitle>J Neuroinflammation</addtitle><date>2024-09-16</date><risdate>2024</risdate><volume>21</volume><issue>1</issue><spage>226</spage><epage>19</epage><pages>226-19</pages><issn>1742-2094</issn><eissn>1742-2094</eissn><abstract>Glioma is the most common primary intracranial tumor in adults, with high incidence, recurrence, and mortality rates. Tumor-associated neutrophils (TANs) are essential components of the tumor microenvironment (TME) in glioma and play a crucial role in glioma cell proliferation, invasion and proneural-mesenchymal transition. Besides the interactions between TANs and tumor cells, the multi-dimensional crosstalk between TANs and other components within TME have been reported to participate in glioma progression. More importantly, several therapies targeting TANs have been developed and relevant preclinical and clinical studies have been conducted in cancer therapy. In this review, we introduce the origin of TANs and the functions of TANs in malignant behaviors of glioma, highlighting the microenvironmental regulation of TANs. Moreover, we focus on summarizing the TANs-targeted methods in cancer therapy, aiming to provide insights into the mechanisms and therapeutic opportunities of TANs in the malignant glioma microenvironment.</abstract><cop>England</cop><pub>BioMed Central Ltd</pub><pmid>39285276</pmid><doi>10.1186/s12974-024-03222-4</doi><tpages>19</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1742-2094
ispartof Journal of neuroinflammation, 2024-09, Vol.21 (1), p.226-19
issn 1742-2094
1742-2094
language eng
recordid cdi_doaj_primary_oai_doaj_org_article_219ce4aacf094f9393d8995a74acf596
source Open Access: PubMed Central; Publicly Available Content (ProQuest)
subjects Animals
Brain Neoplasms - immunology
Brain Neoplasms - pathology
Brain Neoplasms - therapy
Cancer
Care and treatment
Glioma - immunology
Glioma - pathology
Glioma - therapy
Gliomas
Health aspects
Humans
Immunotherapy
Malignant glioma
Neutrophils
Neutrophils - immunology
Neutrophils - pathology
Oncology, Experimental
Physiological aspects
Review
Targeted therapy
Tumor microenvironment
Tumor Microenvironment - immunology
Tumor Microenvironment - physiology
Tumor-associated neutrophils
title Microenvironmental regulation of tumor-associated neutrophils in malignant glioma: from mechanism to therapy
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-08T12%3A28%3A52IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-gale_doaj_&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Microenvironmental%20regulation%20of%20tumor-associated%20neutrophils%20in%20malignant%20glioma:%20from%20mechanism%20to%20therapy&rft.jtitle=Journal%20of%20neuroinflammation&rft.au=Wen,%20Jiayi&rft.date=2024-09-16&rft.volume=21&rft.issue=1&rft.spage=226&rft.epage=19&rft.pages=226-19&rft.issn=1742-2094&rft.eissn=1742-2094&rft_id=info:doi/10.1186/s12974-024-03222-4&rft_dat=%3Cgale_doaj_%3EA808910934%3C/gale_doaj_%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-d374t-8a329c9c3e90d7e3c29756b19c0eec806d1c82210fd8956229eae91edcfc32d23%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=3106045759&rft_id=info:pmid/39285276&rft_galeid=A808910934&rfr_iscdi=true