High frequency of autoimmune thyroiditis in euthyroid girls with premature adrenarche

The purpose of this study was to investigate the frequency of autoimmune thyroiditis (AT) among euthyroid prepubertal girls presenting with premature adrenarche (PA). We also aimed to identify the clinical, metabolic, and endocrine profile of girls with AT and concurrent PA and compare them to girls...

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Bibliographic Details
Published in:Frontiers in pediatrics 2023-03, Vol.11, p.1064177-1064177
Main Authors: Kyritsi, Eleni Magdalini, Vasilakis, Ioannis-Anargyros, Kosteria, Ioanna, Mantzou, Aimilia, Gryparis, Alexandros, Kassi, Eva, Kaltsas, Gregory, Kanaka-Gantenbein, Christina
Format: Article
Language:English
Subjects:
androgens
autoimmune thyroiditis
hyperinsulinemia
leptin
Pediatrics
premature adrenarche
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Summary:The purpose of this study was to investigate the frequency of autoimmune thyroiditis (AT) among euthyroid prepubertal girls presenting with premature adrenarche (PA). We also aimed to identify the clinical, metabolic, and endocrine profile of girls with AT and concurrent PA and compare them to girls with AT without PA, PA alone and healthy controls. Ninety-one prepubertal girls aged 5-10 years, who attended our department for AT, PA and normal variants of growth and puberty were recruited for the study: 73 girls had PA, 6 AT without PA and 12 were referred for investigation of growth. All girls underwent clinical examination, detailed biochemical and hormonal screen. Standard dose Synachten stimulation test (SDSST) and oral glucose tolerance test (OGTT) were performed in all girls with PA. The whole study population was divided in 4 groups: Group PA-/AT+ included 6 girls with AT without PA; Group PA+/AT- PA subjects without AT; Group PA+/AT+ girls with PA and concomitant AT; Group PA-/AT- twelve healthy girls without PA nor AT (controls). Among 73 girls presenting with PA 19 had AT (26%). BMI, systolic blood pressure (SBP) and the presence of goiter significantly differed between the four groups (  = 0.016,  = 0.022 and  
ISSN:2296-2360
2296-2360
DOI:10.3389/fped.2023.1064177