3,5,6,7,8,3',4'-heptamethoxyflavone, a citrus polymethoxylated flavone, attenuates inflammation in the mouse hippocampus

Citrus polymethoxylated flavones (PMFs) have recently been shown to suppress inflammation in peripheral tissues. In the present study, we investigated the effects of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), one of the PMFs, on inflammation in the brain in vivo using mice injected intrahi...

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Bibliographic Details
Published in:Brain sciences 2015-04, Vol.5 (2), p.118-129
Main Authors: Okuyama, Satoshi, Miyoshi, Kazuhiro, Tsumura, Yuichi, Amakura, Yoshiaki, Yoshimura, Morio, Yoshida, Takashi, Nakajima, Mitsunari, Furukawa, Yoshiko
Format: Article
Language:English
Subjects:
3,5,6,7,8,3′,4′-heptamethoxyflavone
anti-inflammation
Brain
Citrus
Communication
hippocampus
IL-1β
Inflammation
microglia
Rodents
Tissues
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Summary:Citrus polymethoxylated flavones (PMFs) have recently been shown to suppress inflammation in peripheral tissues. In the present study, we investigated the effects of 3,5,6,7,8,3',4'-heptamethoxyflavone (HMF), one of the PMFs, on inflammation in the brain in vivo using mice injected intrahippocampally with lipopolysaccharide (LPS). We demonstrated that subcutaneously injected HMF suppressed: (1) LPS-induced losses in body weight; (2) LPS-induced microglial activation in the hippocampus; and (3) LPS-induced interleukin-1β mRNA expression in the hippocampus. These results suggest that HMF has the ability to reduce neuroinflammation in the brain.
ISSN:2076-3425
2076-3425
DOI:10.3390/brainsci5020118