Efficacy of Intact Cord Resuscitation Compared to Immediate Cord Clamping on Cardiorespiratory Adaptation at Birth in Infants with Isolated Congenital Diaphragmatic Hernia (CHIC)

Resuscitation at birth of infants with Congenital Diaphragmatic Hernia (CDH) remains highly challenging because of severe failure of cardiorespiratory adaptation at birth. Usually, the umbilical cord is clamped immediately after birth. Delaying cord clamping while the resuscitation maneuvers are sta...

Full description

Saved in:
Bibliographic Details
Published in:Children (Basel) 2021-04, Vol.8 (5), p.339
Main Authors: Le Duc, Kévin, Mur, Sébastien, Rakza, Thameur, Boukhris, Mohamed Riadh, Rousset, Céline, Vaast, Pascal, Westlynk, Nathalie, Aubry, Estelle, Sharma, Dyuti, Storme, Laurent
Format: Article
Language:English
Subjects:
Apgar score
Babies
Blood pressure
Childrens health
congenital diaphragmatic hernia
delivery room resuscitation
Heart rate
Hernias
Hypoxemia
intact cord resuscitation
Life Sciences
Morbidity
Mortality
Newborn babies
Pediatrics
Pulmonary arteries
Study Protocol
Umbilical cord
Ventilators
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Resuscitation at birth of infants with Congenital Diaphragmatic Hernia (CDH) remains highly challenging because of severe failure of cardiorespiratory adaptation at birth. Usually, the umbilical cord is clamped immediately after birth. Delaying cord clamping while the resuscitation maneuvers are started may: (1) facilitate blood transfer from placenta to baby to augment circulatory blood volume; (2) avoid loss of venous return and decrease in left ventricle filling caused by immediate cord clamping; (3) prevent initial hypoxemia because of sustained uteroplacental gas exchange after birth when the cord is intact. The aim of this trial is to evaluate the efficacy of intact cord resuscitation compared to immediate cord clamping on cardiorespiratory adaptation at birth in infants with isolated CDH. The Congenital Hernia Intact Cord (CHIC) trial is a prospective multicenter open-label randomized controlled trial in two balanced parallel groups. Participants are randomized either immediate cord clamping (the cord will be clamped within the first 15 s after birth) or to intact cord resuscitation group (umbilical cord will be kept intact during the first part of the resuscitation). The primary end-point is the number of infants with APGAR score
ISSN:2227-9067
2227-9067
DOI:10.3390/children8050339