Exosomes for Regulation of Immune Responses and Immunotherapy

Exosomes are membrane-enveloped nanosized (30–150 nm) extracellular vesicles of endosomal origin produced by almost all cell types and encompass a multitude of functioning biomolecules. Exosomes have been considered crucial players of cell-to-cell communication in physiological and pathological cond...

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Bibliographic Details
Published in:Journal of nanotheranostics 2022-03, Vol.3 (1), p.55-85
Main Authors: Hussain, Md Walid Akram, Jahangir, Sarah, Ghosh, Bikona, Yesmin, Farjana, Anis, Afnan, Satil, Sabikun Nahar, Anwar, Faizan, Rashid, Mohammad Harun
Format: Article
Language:English
Subjects:
Apoptosis
Autoimmune diseases
Biomolecules
Breast cancer
Cell growth
Cell interactions
Clinical trials
Communication
Drug carriers
Drug delivery
Exosomes
Extracellular vesicles
immune cells-derived exosomes
Immune response
Immune system
Immunotherapy
Lymphocytes
Medical prognosis
Melanoma
Microscopy
Physiology
Polyethylene glycol
Proteins
Stem cells
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Summary:Exosomes are membrane-enveloped nanosized (30–150 nm) extracellular vesicles of endosomal origin produced by almost all cell types and encompass a multitude of functioning biomolecules. Exosomes have been considered crucial players of cell-to-cell communication in physiological and pathological conditions. Accumulating evidence suggests that exosomes can modulate the immune system by delivering a plethora of signals that can either stimulate or suppress immune responses, which have potential applications as immunotherapies for cancer and autoimmune diseases. Here, we discuss the current knowledge about the active biomolecular components of exosomes that contribute to exosomal function in modulating different immune cells and also how these immune cell-derived exosomes play critical roles in immune responses. We further discuss the translational potential of engineered exosomes as immunotherapeutic agents with their advantages over conventional nanocarriers for drug delivery and ongoing clinical trials.
ISSN:2624-845X
2624-845X
DOI:10.3390/jnt3010005