Postprandial Plasma Glucose Measured from Blood Taken between 4 and 7.9 h Is Positively Associated with Mortality from Hypertension and Cardiovascular Disease

It is unknown whether postprandial plasma glucose measured from blood taken between 4 and 7.9 h (PPG ) is associated with mortality from hypertension, diabetes, or cardiovascular disease (CVD). This study aimed to investigate these associations in 4896 US adults who attended the third National Healt...

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Bibliographic Details
Published in:Journal of cardiovascular development and disease 2024-02, Vol.11 (2), p.53
Main Author: Wang, Yutang
Format: Article
Language:English
Subjects:
Adenosine
Blood pressure
Body mass index
Cardiovascular disease
Cholesterol
Dextrose
Diabetes
Diabetics
Disease prevention
Enzymes
Glucose
Heart attacks
High density lipoprotein
Hypertension
Ischemia
Medical care, Cost of
Missing data
Mortality
non-fasting
Plasma
postprandial
Prevention
Risk factors
Secondary schools
Stroke
Type 2 diabetes
Variables
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Summary:It is unknown whether postprandial plasma glucose measured from blood taken between 4 and 7.9 h (PPG ) is associated with mortality from hypertension, diabetes, or cardiovascular disease (CVD). This study aimed to investigate these associations in 4896 US adults who attended the third National Health and Nutrition Examination Survey. Cox proportional hazards models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) of PPG for mortality. This cohort was followed up for 106,300 person-years (mean follow-up, 21.7 years). A 1-natural-log-unit increase in PPG was associated with a higher risk of mortality from hypertension (HR, 3.50; 95% CI, 2.34-5.24), diabetes (HR, 11.7; 95% CI, 6.85-20.0), and CVD (HR, 2.76; 95% CI, 2.08-3.68) after adjustment for all the tested confounders except hemoglobin A (HbA ). After further adjustment for HbA , PPG remained positively associated with mortality from both hypertension (HR, 2.15; 95% CI, 1.13-4.08) and CVD (HR, 1.62; 95% CI, 1.05-2.51), but was no longer associated with diabetes mortality. Subgroup analyses showed that similar results were obtained in the sub-cohort of participants without a prior diagnosis of myocardial infarction or stroke. In conclusion, PPG predicts mortality from hypertension and CVD, independent of HbA .
ISSN:2308-3425
2308-3425
DOI:10.3390/jcdd11020053