Phosphorylation Signals Downstream of Dopamine Receptors in Emotional Behaviors: Association with Preference and Avoidance

Dopamine regulates emotional behaviors, including rewarding and aversive behaviors, through the mesolimbic dopaminergic pathway, which projects dopamine neurons from the ventral tegmental area to the nucleus accumbens (NAc). Protein phosphorylation is critical for intracellular signaling pathways an...

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Bibliographic Details
Published in:International journal of molecular sciences 2022-10, Vol.23 (19), p.11643
Main Authors: Zhang, Xinjian, Tsuboi, Daisuke, Funahashi, Yasuhiro, Yamahashi, Yukie, Kaibuchi, Kozo, Nagai, Taku
Format: Article
Language:English
Subjects:
Adenosine
Aversion
aversive behavior
Avoidance behavior
Behavior
Cocaine
Dopamine
Dopamine receptors
Emotional behavior
Intracellular
Intracellular signalling
Ion channels
Kinases
Mesolimbic system
Monoamines
Neurotransmitters
Nucleus accumbens
Parkinson's disease
Phosphatase
Phosphorylation
phosphorylation signals
Proteins
Proteomics
Restless legs syndrome
Review
rewarding behavior
Synaptic plasticity
Tetanus
Transcription factors
Ventral tegmentum
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Summary:Dopamine regulates emotional behaviors, including rewarding and aversive behaviors, through the mesolimbic dopaminergic pathway, which projects dopamine neurons from the ventral tegmental area to the nucleus accumbens (NAc). Protein phosphorylation is critical for intracellular signaling pathways and physiological functions, which are regulated by neurotransmitters in the brain. Previous studies have demonstrated that dopamine stimulated the phosphorylation of intracellular substrates, such as receptors, ion channels, and transcription factors, to regulate neuronal excitability and synaptic plasticity through dopamine receptors. We also established a novel database called KANPHOS that provides information on phosphorylation signals downstream of monoamines identified by our kinase substrate screening methods, including dopamine, in addition to those reported in the literature. Recent advances in proteomics techniques have enabled us to clarify the mechanisms through which dopamine controls rewarding and aversive behaviors through signal pathways in the NAc. In this review, we discuss the intracellular phosphorylation signals regulated by dopamine in these two emotional behaviors.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms231911643