18F-Florbetaben Amyloid PET Imaging: A Chinese Study in Cognitive Normal Controls, Mild Cognitive Impairment, and Alzheimer’s Disease Patients

Objective: To evaluate amyloid-β deposition with 18F-Florbetaben (FBB) PET imaging against 11C-PIB PET in cognitive normal controls (NC), mild cognitive impairment (MCI) and Alzheimer’s disease patients. Methods: We recruited 45 subjects (15 in each group of NC, MCI and mild/moderate AD) who had und...

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Bibliographic Details
Published in:Frontiers in neuroscience 2020-07, Vol.14, p.745-745
Main Authors: Chang, Yan, Li, Can, Yang, Hui, Wu, Yue, Xu, Baixuan, Zhang, Jinming, Wang, Ruimin
Format: Article
Language:English
Subjects:
Alzheimer's disease
Amyloid
amyloid beta
amyloid imaging
Biomarkers
Brain research
Cerebellum
Cognitive ability
Computed tomography
Dementia
Disease
FDA approval
florbetaben
Histopathology
Hospitals
Medical imaging
Mental disorders
Neurodegenerative diseases
Neuroscience
Nuclear medicine
PET
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Summary:Objective: To evaluate amyloid-β deposition with 18F-Florbetaben (FBB) PET imaging against 11C-PIB PET in cognitive normal controls (NC), mild cognitive impairment (MCI) and Alzheimer’s disease patients. Methods: We recruited 45 subjects (15 in each group of NC, MCI and mild/moderate AD) who had undergone dynamic 18F-FBB amyloid PET imaging. For comparison study, 17 participants, including 6 NC, 5 MCI and 6 AD patients, were also performed 11C-PIB PET imaging on separate days. Standardized uptake value ratio (SUVR) were calculated using the cerebellum as reference region with regions of interest (ROIs) manually defined on co-registered CT. Quantitative analysis of mean cortical uptake was calculated using global SUVR. Results: 1 (7%) of the 15 NC participants, 9 (60%) of 15 MCI patients and 12 (80%) of 15 AD patients had amyloid-positive lesions on 18F-FBB PET images. In AD patients, global SUVR was significantly higher than those of MCI patients (1.73±0.62 vs. 1.55±0.11, P
ISSN:1662-453X
1662-4548
1662-453X
DOI:10.3389/fnins.2020.00745