Pycnogenol a promising remedy for diabetic keratopathy in experimentally induced corneal alkali burns in diabetic rats

This study aimed to investigate the efficiency of topically applied pycnogenol (PYC) in healing the standardized alkaline corneal ulcer in diabetic and normal rats. The corneal alkali-burn injury (CA-I) model was unilaterally developed in Wistar rats by filter paper saturated with 0.01 M of NaOH and...

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Bibliographic Details
Published in:BMC veterinary research 2022-05, Vol.18 (1), p.209-10, Article 209
Main Authors: Hamed, Mohamed A, Farag, Amany, Zahran, Ibrahim S, Hafez, Ahmed, Rizk, Mohamed Abdo, Abass, Marwa
Format: Article
Language:English
Subjects:
Alkalies - therapeutic use
Alkalies - toxicity
Animal models
Animals
Burns
Burns, Chemical - drug therapy
Burns, Chemical - pathology
Burns, Chemical - veterinary
Care and treatment
Collagen
Complications and side effects
Cornea
Corneal diseases
Corneal Diseases - veterinary
Diabetes
Diabetes mellitus
Diabetes Mellitus, Experimental - chemically induced
Diabetes Mellitus, Experimental - complications
Diabetic retinopathy
Diagnosis
Edema
Endothelium
Epithelium
Filter paper
Flavonoids
Hyaluronic acid
Hyperglycemia
Inflammation
Oxidative stress
Plant Extracts
Pycnogenol
Rats
Rats, Wistar
Risk factors
Rodents
Sodium hydroxide
Ulcers
Wound healing
Wounds and injuries
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Summary:This study aimed to investigate the efficiency of topically applied pycnogenol (PYC) in healing the standardized alkaline corneal ulcer in diabetic and normal rats. The corneal alkali-burn injury (CA-I) model was unilaterally developed in Wistar rats by filter paper saturated with 0.01 M of NaOH and touching the eyes for 45 s. Rats were divided into four groups: Normal control (NC), normal PYC (NPYC), diabetic control (DC), and diabetic PYC (DPYC). Both NPYC and DPYC groups were daily treated with PY eye drops three times, whereas NC and DC ones were treated with ordinary saline for six successive days. The wound healing of corneal epithelial was improved in the NPYC group compared to the NC group. Meanwhile, it was significantly improved (P 
ISSN:1746-6148
1746-6148
DOI:10.1186/s12917-022-03307-3