An NADPH sensor that regulates cell ferroptosis

Ferroptosis is a new form of programmed cell death, which achieved great breakthroughs in cell biology during past decade. However, the regulation of ferroptosis is yet to be identified thoroughly. The latest study published on Nature cell biology by Nguyen and colleagues found a new NADPH sensor, M...

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Bibliographic Details
Published in:Journal of translational medicine 2022-10, Vol.20 (1), p.1-474, Article 474
Main Authors: Kuang, Guixing, Wang, Weidong, Xiong, Dan, Zeng, Chong
Format: Article
Language:English
Subjects:
Ablation
Antioxidants
Apoptosis
Birth rate
Cancer
Care and treatment
Cell death
Chemical properties
Diagnosis
Energy metabolism
Ferroptosis
Health aspects
Kinases
Lipid peroxidation
Lipids
MARCHF6
Metabolism
Metabolites
NADP (Coenzyme)
NADPH
Nervous system diseases
Physiology
Risk factors
Sensors
Tumorigenesis
Tumors
Ubiquitin
Ubiquitin-protein ligase
Ubiquitination
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Summary:Ferroptosis is a new form of programmed cell death, which achieved great breakthroughs in cell biology during past decade. However, the regulation of ferroptosis is yet to be identified thoroughly. The latest study published on Nature cell biology by Nguyen and colleagues found a new NADPH sensor, MARCHF6 an E3 ubiquitin ligase, mediates ferroptosis in tumor growth and animal development. This finding provides a novel insight into ubiquitin system and energy metabolism in regulation of ferroptosis, which may open up new avenues for tumor treatment.
ISSN:1479-5876
1479-5876
DOI:10.1186/s12967-022-03658-3