Attentional network deficits in patients with migraine: behavioral and electrophysiological evidence

• Published in: Journal of headache and pain 2024-11, Vol.25 (1), p.195-16, Article 195
• Main Authors: Chen, Yuxin, Xie, Siyuan, Zhang, Libo, Li, Desheng, Su, Hui, Wang, Rongfei, Ao, Ran, Lin, Xiaoxue, Liu, Yingyuan, Zhang, Shuhua, Zhai, Deqi, Sun, Yin, Wang, Shuqing, Hu, Li, Dong, Zhao, Lu, Xuejing
• Format: Article
• Language: English
• Subjects: Adult; Arousal; Arousal - physiology; Attention; Attention - physiology; Clinical trials; Cognition & reasoning; Disease management; EEG; Electroencephalography; Electroencephalography (EEG); Event-related potentials; Executive function; Executive Function - physiology; Female; Headache; Headaches; Humans; Hypersensitivity; Internal Medicine; Latency; Machine learning; Male; Medical diagnosis; Medicine; Medicine & Public Health; Middle Aged; Migraine; Migraine Disorders - complications; Migraine Disorders - physiopathology; Neurology; Pain; Pain Medicine; Patients; Synchronization; Vigilance; Visual cortex; Young Adult
• ISSN: 1129-2377; 1129-2369; 1129-2377
• DOI: 10.1186/s10194-024-01905-0

Background Patients with migraine often experience not only headache pain but also cognitive dysfunction, particularly in attention, which is frequently overlooked in both diagnosis and treatment. The influence of these attentional deficits on the pain-related clinical characteristics of migraine remains poorly understood, and clarifying this relationship could improve care strategies. Methods This study included 52 patients with migraine and 34 healthy controls. We employed the Attentional Network Test for Interactions and Vigilance–Executive and Arousal Components paradigm, combined with electroencephalography, to assess attentional deficits in patients with migraine, with an emphasis on phasic alerting, orienting, executive control, executive vigilance, and arousal vigilance. An extreme gradient boosting binary classifier was trained on features showing group differences to distinguish patients with migraine from healthy controls. Moreover, an extreme gradient boosting regression model was developed to predict clinical characteristics of patients with migraine using their attentional deficit features. Results For general performance, patients with migraine presented a larger inverse efficiency score, a higher prestimulus beta-band power spectral density and a lower gamma-band event-related synchronization at Cz electrode, and stronger high alpha-band activity at the primary visual cortex, compared to healthy controls. Although no behavior differences in three basic attentional networks were found, patients showed magnified N1 amplitude and prolonged latency of P2 for phasic alerting-trials as well as an increased orienting evoked-P1 amplitude. For vigilance function, improvements in the hit rate of executive vigilance-trials were exhibited in controls but not in patients. Besides, patients with migraine exhibited longer reaction time as well as larger variability in arousal vigilance-trials than controls. The binary classifier developed by such attentional deficit features achieved an F1 score of 0.762 and an accuracy of 0.779 in distinguishing patients with migraine from healthy controls. Crucially, the predicted value available from the regression model involving attentional deficit features significantly correlated with the real value for the frequency of headache. Conclusions Patients with migraine demonstrated significant attentional deficits, which can be used to differentiate migraine patients from healthy populations and to predict clinical char