Autoimmunity: Are we asking the right question?

For decades, the main question immunologists have asked about autoimmunity is “what causes a break in self-tolerance?” We have not found good answers to that question, and I believe we are still so ignorant because it’s the wrong question. Rather than a break in self-tolerance, I suggest that many a...

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Bibliographic Details
Published in:Frontiers in immunology 2022-11, Vol.13, p.864633-864633
Main Author: Matzinger, Polly
Format: Article
Language:English
Subjects:
autoimmunity
autoreactivity
Immunology
programmed cell death, danger model
T helper cells (Th cells)
tissue resident cells
tissue-based class control
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Summary:For decades, the main question immunologists have asked about autoimmunity is “what causes a break in self-tolerance?” We have not found good answers to that question, and I believe we are still so ignorant because it’s the wrong question. Rather than a break in self-tolerance, I suggest that many autoimmune diseases might be due to defects in normal tissue physiology.
ISSN:1664-3224
1664-3224
DOI:10.3389/fimmu.2022.864633