Inspection of Histological 3D Reconstructions in Virtual Reality

3D reconstruction is a challenging current topic in medical research. We perform 3D reconstructions from serial sections stained by immunohistological methods. This paper presents an immersive visualization solution to quality control (QC), inspect, and analyze such reconstructions. QC is essential...

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Bibliographic Details
Published in:Frontiers in virtual reality 2021-05, Vol.2
Main Authors: Lobachev, Oleg, Berthold, Moritz, Pfeffer, Henriette, Guthe, Michael, Steiniger, Birte S.
Format: Article
Language:English
Subjects:
3D reconstruction
anatomy
histological serial sections
scientific visualization
virtual reality
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Summary:3D reconstruction is a challenging current topic in medical research. We perform 3D reconstructions from serial sections stained by immunohistological methods. This paper presents an immersive visualization solution to quality control (QC), inspect, and analyze such reconstructions. QC is essential to establish correct digital processing methodologies. Visual analytics, such as annotation placement, mesh painting, and classification utility, facilitates medical research insights. We propose a visualization in virtual reality (VR) for these purposes. In this manner, we advance the microanatomical research of human bone marrow and spleen. Both 3D reconstructions and original data are available in VR. Data inspection is streamlined by subtle implementation details and general immersion in VR.
ISSN:2673-4192
2673-4192
DOI:10.3389/frvir.2021.628449