Recovery of brain DHA-containing phosphatidylserine and ethanolamine plasmalogen after dietary DHA-enriched phosphatidylcholine and phosphatidylserine in SAMP8 mice fed with high-fat diet

• Published in: Lipids in health and disease 2020-05, Vol.19 (1), p.104-104, Article 104
• Main Authors: Zhao, Ying-Cai, Zhou, Miao-Miao, Zhang, Ling-Yu, Cong, Pei-Xu, Xu, Jie, Xue, Chang-Hu, Yanagita, Teruyoshi, Chi, Naiqiu, Zhang, Tian-Tian, Liu, Feng-Hai, Wang, Yu-Ming
• Format: Article
• Language: English
• Subjects: Alzheimer Disease; Alzheimer's disease; Animal cognition; Animals; Cerebral cortex; Cerebral Cortex - chemistry; Cerebral Cortex - drug effects; Chromatography; Cognitive ability; Dementia; Dementia disorders; DHA; Diet; Diet, High-Fat; Dietary supplements; Disease Models, Animal; Docosahexaenoic Acids - analysis; Ethanolamine; Ethanolamines; Fatty acids; High fat diet; Homeostasis; Kinases; Lecithin; Lipid profile; Lipidomics; Lipids; Low fat diet; Male; Mass spectrometry; Memory; Mice; Nervous system; Nutrient deficiency; Nutrition research; Phosphatidylcholine; Phosphatidylcholines - chemistry; Phosphatidylcholines - pharmacology; Phosphatidylserine; Phosphatidylserines - analysis; Phosphatidylserines - chemistry; Phosphatidylserines - metabolism; Phosphatidylserines - pharmacology; Phospholipids; Plasmalogens - analysis; Plasmalogens - chemistry; Plasmalogens - metabolism; Scientific imaging
• ISSN: 1476-511X; 1476-511X
• DOI: 10.1186/s12944-020-01253-3

Glycerophospholipids were the main components of cerebral cortex lipids, and there was a close association between lipid homeostasis and human health. It has been reported that dietary DHA-enriched phosphatidylcholine (DHA-PC) and phosphatidylserine (DHA-PS) could improve brain function. However, it was unclear that whether supplementation of DHA-PC and DHA-PS could change lipid profiles in the brain of dementia animals. SAMP8 mice was fed with different diet patterns for 2 months, including high-fat diet and low-fat diet. After intervention with DHA-PC and DHA-PS for another 2 months, the lipid profile in cerebral cortex was determined by lipidomics in dementia mice. High-fat diet could significantly decrease the levels of DHA-containing PS/pPE, DPA-containing PS, and AA-containing PE, which might exhibit the potential of lipid biomarkers for the prevention and diagnosis of AD. Notably, DHA-PC and DHA-PS remarkably recovered the lipid homeostasis in dementia mice. These might provide a potential novel therapy strategy and direction of dietary intervention for patients with cognitive decline. DHA-PC and DHA-PS could recover the content of brain DHA-containing PS and pPE in SAMP8 mice fed with high-fat diet.