Urinary levels of organophosphate flame retardants metabolites in a young population from Southern Taiwan and potential health effects

Organophosphate flame retardants (OPFRs) are widely distributed in the environment and their metabolites are observed in urine, but little is known regarding OPFRs in a broad-spectrum young population from newborns to those aged 18 years. Investigate urinary levels of OPFRs and OPFR metabolites in T...

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Published in:Frontiers in endocrinology (Lausanne) 2023-06, Vol.14, p.1173449-1173449
Main Authors: Chen, Feng-Shun, Chen, Chih-Cheng, Tsai, Ching-Chang, Lu, Jian-He, You, Huey-Ling, Chen, Ching-Mei, Huang, Wan-Ting, Tsai, Kai-Fan, Cheng, Fu-Jen, Kung, Chia-Te, Li, Shau-Hsuan, Wang, Chin-Chou, Ou, Yu-Che, Lee, Wen-Chin, Chang, Yu-Ting, Hashim, Fahimah, Chao, How-Ran, Wang, Liang-Jen
Format: Article
Language:English
Subjects:
a broad-spectrum pediatric population
Adolescent
Child
Child, Preschool
Endocrinology
Flame Retardants
hazardous chemicals
Health Status
Humans
Infant, Newborn
newborn
OPFR metabolites
organophosphate flame retardants (OPFRs)
Organophosphates - metabolism
Taiwan - epidemiology
urine
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Summary:Organophosphate flame retardants (OPFRs) are widely distributed in the environment and their metabolites are observed in urine, but little is known regarding OPFRs in a broad-spectrum young population from newborns to those aged 18 years. Investigate urinary levels of OPFRs and OPFR metabolites in Taiwanese infants, young children, schoolchildren, and adolescents within the general population. Different age groups of subjects (n=136) were recruited from southern Taiwan to detect 10 OPFR metabolites in urine samples. Associations between urinary OPFRs and their corresponding metabolites and potential health status were also examined. The mean level of urinary Σ OPFR in this broad-spectrum young population is 2.25 μg/L (standard deviation (SD) of 1.91 μg/L). Σ OPFR metabolites in urine are 3.25 ± 2.84, 3.06 ± 2.21, 1.75 ± 1.10, and 2.32 ± 2.29 μg/L in the age groups comprising of newborns, 1-5 year-olds, 6-10 year-olds, and 11-18 year-olds, respectively, and borderline significant differences were found in the different age groups ( =0.125). The OPFR metabolites of TCEP, BCEP, DPHP, TBEP, DBEP, and BDCPP predominate in urine and comprise more than 90% of the total. TBEP was highly correlated with DBEP in this population (r=0.845,
ISSN:1664-2392
1664-2392
DOI:10.3389/fendo.2023.1173449