Renal Morphology in Coronavirus Disease: A Literature Review

• Published in: Medicina (Kaunas, Lithuania) Lithuania), 2021-03, Vol.57 (3), p.258
• Main Authors: de Oliveira, Patrick, Cunha, Kaile, Neves, Precil, Muniz, Monique, Gatto, Giuseppe, Salgado Filho, Natalino, Guedes, Felipe, Silva, Gyl
• Format: Article
• Language: English
• Subjects: Acute Kidney Injury - blood; Acute Kidney Injury - immunology; Acute Kidney Injury - pathology; Adaptive Immunity - immunology; Arteriosclerosis - immunology; Arteriosclerosis - pathology; coronavirus; Coronaviruses; COVID-19; COVID-19 - blood; COVID-19 - immunology; COVID-19 - pathology; Cytokines - immunology; Glomerulonephritis - immunology; Glomerulonephritis - pathology; Glomerulonephritis, IGA - immunology; Glomerulonephritis, IGA - pathology; Glomerulosclerosis, Focal Segmental - immunology; Glomerulosclerosis, Focal Segmental - pathology; Humans; Immunity, Innate - immunology; Infarction - immunology; Infarction - pathology; Kidney - blood supply; Kidney - immunology; Kidney - pathology; Kidney Cortex Necrosis - immunology; Kidney Cortex Necrosis - pathology; Kidneys; Nephritis, Interstitial - immunology; Nephritis, Interstitial - pathology; Nephrosis, Lipoid - immunology; Nephrosis, Lipoid - pathology; renal biopsy; renal morphology; Review; Rhabdomyolysis; SARS-CoV-2; Thrombophilia - blood; Thrombotic Microangiopathies - immunology; Thrombotic Microangiopathies - pathology; Viral infections
• ISSN: 1648-9144; 1010-660X; 1648-9144
• DOI: 10.3390/medicina57030258

Renal biopsy is useful to better understand the histological pattern of a lesion (glomerular, tubulointerstitial, and vascular) and the pathogenesis that leads to kidney failure. The potential impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) on the kidneys is still undetermined, and a variety of lesions are seen in the kidney tissue of coronavirus disease patients. This review is based on the morphological findings of patients described in case reports and a series of published cases. A search was conducted on MEDLINE and PubMed of case reports and case series of lesions in the presence of non-critical infection by SARS-CoV-2 published until 15/09/2020. We highlight the potential of the virus directly influencing the damage or the innate and adaptive immune response activating cytokine and procoagulant cascades, in addition to the genetic component triggering glomerular diseases, mainly collapsing focal segmental glomerulosclerosis, tubulointerstitial, and even vascular diseases. Kidney lesions caused by SARS-CoV-2 are frequent and have an impact on morbidity and mortality; thus, studies are needed to assess the morphological kidney changes and their mechanisms and may help define their spectrum and immediate or long-term impact.