Cerebral infarction associated with benign mucin-producing adenomyosis: report of two cases

Cerebral infarction associated with a malignant tumor is widely recognized as Trousseau syndrome. In contrast, few cases of cerebral infarction associated with benign tumors have been reported. We present two cases of embolic stroke that seemed to be caused by mucin-producing adenomyosis. The patien...

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Bibliographic Details
Published in:BMC neurology 2018-10, Vol.18 (1), p.166-166, Article 166
Main Authors: Okazaki, Koki, Oka, Fumiaki, Ishihara, Hideyuki, Suzuki, Michiyasu
Format: Article
Language:English
Subjects:
Adenomyosis
Adenomyosis - complications
Adult
Aphasia
Benign
Benign tumor
Case Report
Case reports
Cerebral infarction
Cerebral Infarction - etiology
Complications and side effects
Diagnosis
Endometriosis
Female
Hemispheric laterality
Humans
Hypercoagulation
Literature reviews
Medical imaging
Middle Aged
Mucin
Mucins
Mucins - metabolism
NMR
Nuclear magnetic resonance
Paresis
Risk factors
Stroke
Trousseau’s syndrome
Tumors
Uterus
Veins & arteries
Women
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Summary:Cerebral infarction associated with a malignant tumor is widely recognized as Trousseau syndrome. In contrast, few cases of cerebral infarction associated with benign tumors have been reported. We present two cases of embolic stroke that seemed to be caused by mucin-producing adenomyosis. The patients were women aged 42 and 50 years old. Both patients developed right hemiparesis and aphasia, and cerebral infarctions were detected in the left cerebral hemisphere. There were no other abnormal findings, except for elevation of CA125 and D-dimer. Trousseau syndrome was suspected in both cases, but whole body examinations did not reveal any malignant tumors. However, uterine adenomyosis was detected in both patients. From our findings and a review of the literature, both mucin-producing malignant tumors and mucin-producing benign tumors such as adenomyosis may cause hypercoagulability and cerebral infarction. This mechanism should be considered in a case of a young to middle-aged woman with embolic stroke of an undetermined origin.
ISSN:1471-2377
1471-2377
DOI:10.1186/s12883-018-1169-2