Determination of cetirizine in tablets and compounded capsules: comparative study between CE and HPLC

A capillary electrophoresis (CE) method was developed and validated for determination of cetirizine dihydrochloride in tablets and compounded capsules. The electrophoretic separation was performed in an uncoated fused-silica capillary (40 cm x 50 μm i.d.) using 20 mmol L-1 sodium tetraborate buffer...

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Bibliographic Details
Published in:Química Nova 2010, Vol.33 (1), p.114-118
Main Authors: Bajerski, Lisiane, Sangoi, Maximiliano da Silva, Barth, Thiago, Diefenbach, Isabel Fração, Dalmora, Sérgio Luís, Cardoso, Simone Gonçalves
Format: Article
Language:English
Subjects:
capillary eletrophoresis
cetirizine
CHEMISTRY, MULTIDISCIPLINARY
high performance liquid chromatography
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Summary:A capillary electrophoresis (CE) method was developed and validated for determination of cetirizine dihydrochloride in tablets and compounded capsules. The electrophoretic separation was performed in an uncoated fused-silica capillary (40 cm x 50 μm i.d.) using 20 mmol L-1 sodium tetraborate buffer (pH 9.3) as background electrolyte, a hydrodinamic sample injection at 50 mBar for 5 s, 20 KV applied voltage at 25 °C, and detection at 232 nm. The proposed method was compared with the high performance liquid chromatographic (HPLC) method previously validated for this drug, and statistical analysis showed no significant difference between the techniques.
ISSN:0100-4042
1678-7064
1678-7064
DOI:10.1590/S0100-40422010000100021