Neurophysiological markers of ADHD symptoms in typically-developing children

• Published in: Scientific reports 2020-12, Vol.10 (1), p.22460-22460, Article 22460
• Main Authors: Hilger, Kirsten, Sassenhagen, Jona, Kühnhausen, Jan, Reuter, Merle, Schwarz, Ulrike, Gawrilow, Caterina, Fiebach, Christian J.
• Format: Article
• Language: English
• Subjects: 631/378/2649/1310; 631/378/2649/2150; Attention; Attention Deficit Disorder with Hyperactivity - diagnosis; Attention Deficit Disorder with Hyperactivity - epidemiology; Attention Deficit Disorder with Hyperactivity - psychology; Attention deficit hyperactivity disorder; Biomarkers; Child; Children; Cognition; Electroencephalography; Event-related potentials; Evoked Potentials; Executive function; Female; Humanities and Social Sciences; Humans; Hyperactivity; Impulsive behavior; Inhibition, Psychological; Male; multidisciplinary; Science; Science (multidisciplinary); Social Behavior; Surveys and Questionnaires; Symptom Assessment
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-020-80562-0

Children with attention-deficit/hyperactivity disorder (ADHD) are characterized by symptoms of inattention, impulsivity, and hyperactivity. Neurophysiological correlates of ADHD include changes in the P3 component of event-related brain potentials (ERPs). Motivated by recent advances towards a more dimensional understanding of ADHD, we investigate whether ADHD-related ERP markers relate to continuous variations in attention and executive functioning also in typically-developing children. ERPs were measured while 31 school children (9–11 years) completed an adapted version of the Continuous Performance Task that additionally to inhibitory processes also isolates effects of physical stimulus salience. Children with higher levels of parent-reported ADHD symptoms did not differ in task performance, but exhibited smaller P3 amplitudes related to stimulus salience. Furthermore, ADHD symptoms were associated with the variability of neural responses over time: Children with higher levels of ADHD symptoms demonstrated lower variability in inhibition- and salience-related P3 amplitudes. No effects were observed for ERP latencies and the salience-related N2. By demonstrating that ADHD-associated neurophysiological mechanisms of inhibition and salience processing covary with attention and executive functioning in a children community sample, our study provides neurophysiological support for dimensional models of ADHD. Also, temporal variability in event-related potentials is highlighted as additional indicator of ADHD requiring further investigation.