An in vivo confocal microscopy study of corneal changes in patients with systemic sclerosis

To investigate corneal microstructure of systemic sclerosis (SSc) patients using in vivo confocal microscopy (IVCM). 33 patients with SSc and 30 age-matched healthy subjects were recruited. All participants underwent comprehensive ophthalmic examination including IVCM (Heidelberg Retina Tomograph II...

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Bibliographic Details
Published in:Scientific reports 2021-05, Vol.11 (1), p.11111-7, Article 11111
Main Authors: Szalai, Eszter, Szucs, Gabriella, Szamosi, Szilvia, Aszalos, Zsuzsa, Afra, Ildiko, Kemeny-Beke, Adam
Format: Article
Language:English
Subjects:
692/4023
692/4023/1670
692/4023/1671
Aged
Case-Control Studies
Cell Count
Cornea - metabolism
Corneal Keratocytes - metabolism
Cross-Sectional Studies
Female
Humanities and Social Sciences
Humans
Male
Microscopy, Confocal
Middle Aged
multidisciplinary
Science
Science (multidisciplinary)
Scleroderma, Systemic - metabolism
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Summary:To investigate corneal microstructure of systemic sclerosis (SSc) patients using in vivo confocal microscopy (IVCM). 33 patients with SSc and 30 age-matched healthy subjects were recruited. All participants underwent comprehensive ophthalmic examination including IVCM (Heidelberg Retina Tomograph III, Heidelberg Engineering GmbH, Heidelberg, Germany) and ocular surface evaluation. Subbasal nerve plexus morphology was investigated using automated software analysis (ACCMetrics V3; University of Manchester, Manchester, UK). Keratocyte cell densities in the anterior stroma were significantly lower in patients with SSc compared to controls (P 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-90594-9