Glycyrrhiza polysaccharides can improve and prolong the response of chickens to the Newcastle disease vaccine

• Published in: Poultry science 2022-01, Vol.101 (1), p.101549, Article 101549
• Main Authors: Wu, Yu, Li, Nannan, Zhang, Tao, Che, Yanyun, Duan, Kun, Wang, Yuedi, Zhou, Hui, Wan, Xin, Lei, Hongjun, Nguyễn, Audrey D, De Souza, Cristabelle, Li, Kun, Wu, Yi, Liu, Jiaguo, Wang, Deyun
• Format: Article
• Language: English
• Subjects: Animals; Chickens; Glycyrrhiza; Glycyrrhiza polysaccharides; immune booster; immune response; IMMUNOLOGY, HEALTH AND DISEASE; Newcastle disease; Newcastle Disease - prevention & control; Polysaccharides; Vaccines
• ISSN: 0032-5791; 1525-3171; 1525-3171
• DOI: 10.1016/j.psj.2021.101549

Licorice is a medicinal and food plant widely used to treat diseases and produce food additives, because of its unique chemical constituents like polysaccharides, flavones, and saponins. Glycyrrhiza Polysaccharides (GPS-1) are water-soluble neutral polysaccharides extracted from licorice. Currently, GPS-1 is administrated to chickens by gavage every d for 14 d to observe the impact of GPS-1 on the Newcastle disease vaccine. To determine the immunity of these chickens to NDV, blood serum levels of hemagglutinin-inhibition (HI) antibody, and immunoglobulins IgA and IgG were measured. Meanwhile, the expression levels of cytokines IL-2, IL-4, IL-17, and IFN-γ were measured to evaluate the degree of immune booster activity. The chickens’ spleen and peripheral blood lymphocytes displayed a significant increase in the proportion of CD4+ and CD8+ T cells after booster treatments with GPS-1. The results indicated that GPS-1 had a significant, dose-dependent, immune-boosting effect which could enhance NDV vaccine immunity in chickens.