Staphylococcus aureus Toxins and Diabetic Foot Ulcers: Role in Pathogenesis and Interest in Diagnosis

Infection of foot ulcers is a common, often severe and costly complication in diabetes. Diabetic foot infections (DFI) are mainly polymicrobial, and Staphylococcus aureus is the most frequent pathogen isolated. The numerous virulence factors and toxins produced by S. aureus during an infection are w...

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Bibliographic Details
Published in:Toxins 2016-07, Vol.8 (7), p.209
Main Authors: Dunyach-Remy, Catherine, Ngba Essebe, Christelle, Sotto, Albert, Lavigne, Jean-Philippe
Format: Article
Language:English
Subjects:
Bacterial Toxins - metabolism
Diabetic Foot - diagnosis
Diabetic Foot - epidemiology
Diabetic Foot - microbiology
Diabetic Foot - therapy
diabetic foot infection
Host-Pathogen Interactions
Humans
Life Sciences
Osteomyelitis - diagnosis
Osteomyelitis - epidemiology
Osteomyelitis - microbiology
Osteomyelitis - therapy
Prognosis
Review
Risk Factors
Staphylococcal Infections - diagnosis
Staphylococcal Infections - epidemiology
Staphylococcal Infections - microbiology
Staphylococcal Infections - therapy
Staphylococcus aureus
Staphylococcus aureus - metabolism
Staphylococcus aureus - pathogenicity
Toxicology
toxins
Virulence
Virulence Factors - metabolism
Wound Infection - diagnosis
Wound Infection - epidemiology
Wound Infection - microbiology
Wound Infection - therapy
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Summary:Infection of foot ulcers is a common, often severe and costly complication in diabetes. Diabetic foot infections (DFI) are mainly polymicrobial, and Staphylococcus aureus is the most frequent pathogen isolated. The numerous virulence factors and toxins produced by S. aureus during an infection are well characterized. However, some particular features could be observed in DFI. The aim of this review is to describe the role of S. aureus in DFI and the implication of its toxins in the establishment of the infection. Studies on this issue have helped to distinguish two S. aureus populations in DFI: toxinogenic S. aureus strains (harboring exfoliatin-, EDIN-, PVL- or TSST-encoding genes) and non-toxinogenic strains. Toxinogenic strains are often present in infections with a more severe grade and systemic impact, whereas non-toxinogenic strains seem to remain localized in deep structures and bone involving diabetic foot osteomyelitis. Testing the virulence profile of bacteria seems to be a promising way to predict the behavior of S. aureus in the chronic wounds.
ISSN:2072-6651
2072-6651
DOI:10.3390/toxins8070209