Convolutional neural network based on automatic segmentation of peritumoral shear-wave elastography images for predicting breast cancer

• Published in: Frontiers in oncology 2023-02, Vol.13, p.1099650-1099650
• Main Authors: Xie, Li, Liu, Zhen, Pei, Chong, Liu, Xiao, Cui, Ya-Yun, He, Nian-An, Hu, Lei
• Format: Article
• Language: English
• Subjects: breast cancer; convolutional neural networks (CNN); Oncology; peritumoral stiffness; segmentation; shear-wave elastography (SWE)
• ISSN: 2234-943X; 2234-943X
• DOI: 10.3389/fonc.2023.1099650

Our aim was to develop dual-modal CNN models based on combining conventional ultrasound (US) images and shear-wave elastography (SWE) of peritumoral region to improve prediction of breast cancer. We retrospectively collected US images and SWE data of 1271 ACR- BIRADS 4 breast lesions from 1116 female patients (mean age ± standard deviation, 45.40 ± 9.65 years). The lesions were divided into three subgroups based on the maximum diameter (MD): ≤15 mm; >15 mm and ≤25 mm; >25 mm. We recorded lesion stiffness (SWV1) and 5-point average stiffness of the peritumoral tissue (SWV5). The CNN models were built based on the segmentation of different widths of peritumoral tissue (0.5 mm, 1.0 mm, 1.5 mm, 2.0 mm) and internal SWE image of the lesions. All single-parameter CNN models, dual-modal CNN models, and quantitative SWE parameters in the training cohort (971 lesions) and the validation cohort (300 lesions) were assessed by receiver operating characteristic (ROC) curve. The US + 1.0 mm SWE model achieved the highest area under the ROC curve (AUC) in the subgroup of lesions with MD ≤15 mm in both the training (0.94) and the validation cohorts (0.91). In the subgroups with MD between15 and 25 mm and above 25 mm, the US + 2.0 mm SWE model achieved the highest AUCs in both the training cohort (0.96 and 0.95, respectively) and the validation cohort (0.93 and 0.91, respectively). The dual-modal CNN models based on the combination of US and peritumoral region SWE images allow accurate prediction of breast cancer.