Plasma fibrinogen acts as a predictive factor for pathological complete response to neoadjuvant chemotherapy in breast cancer: a retrospective study of 1004 Chinese breast cancer patients

The aim of this study was to evaluate the relationship between pre-treatment plasma fibrinogen (Fib) level and pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer patients and to assess the role of plasma Fib as a predictive factor. Data from 1004 consecutive pati...

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Bibliographic Details
Published in:BMC cancer 2021-05, Vol.21 (1), p.542-542, Article 542
Main Authors: Wang, Yihua, Wang, Yu, Chen, Rui, Tang, Zhenrong, Peng, Yang, Jin, Yudi, Lan, Ailin, Ding, Nan, Dai, Yuran, Jiang, Linshan, Liu, Shengchun
Format: Article
Language:English
Subjects:
Adjuvant treatment
Angiogenesis
Breast cancer
Cancer
Cancer therapies
Care and treatment
Chemotherapy
Coagulation factor
Development and progression
Fibrinogen
Genetic aspects
Health aspects
Histology
Hormone replacement therapy
Invasiveness
Lymphatic system
Medical prognosis
Metastasis
Pathological complete response
Patients
Plasma
Predictive ability
Prognosis
Surgery
Survival
Tumors
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Summary:The aim of this study was to evaluate the relationship between pre-treatment plasma fibrinogen (Fib) level and pathological complete response (pCR) to neoadjuvant chemotherapy (NAC) in breast cancer patients and to assess the role of plasma Fib as a predictive factor. Data from 1004 consecutive patients with invasive breast cancer who received NAC and subsequent surgery were retrospectively analysed. Both univariate and multivariate analyses based on logistic regression model were performed to identify clinicopathological factors associated with pCR to NAC. Cox regression model was used to determine the correlation between clinical or pathological parameters and recurrence-free survival (RFS). The Kaplan-Meier method and the log-rank test were applied in the survival analysis. The median value of Fib, rather than other plasma coagulation parameters, was significantly increased in non-pCR patients compared with pCR patients (P = 0.002). Based on the cut-off value estimated by the receiver operating characteristic (ROC) curve analysis, patients were divided into low or high Fib groups (Fib
ISSN:1471-2407
1471-2407
DOI:10.1186/s12885-021-08284-8