Comprehensive prognosis assessment of cardiovascular magnetic resonance parametric mapping in light chain amyloidosis

• Published in: Journal of cardiovascular magnetic resonance 2025, Vol.27 (1), p.101135, Article 101135
• Main Authors: Li, Xiao, Guo, Yubo, Shen, Kaini, Huang, Sisi, Gao, Yajuan, Lin, Lu, Wang, Jian, Cao, Jian, Cao, Xinxin, Jin, Zhengyu, Zhang, Zhuoli, Varga-Szemes, Akos, Schoepf, U. Joseph, Li, Jian, Wang, Yining
• Format: Article
• Language: English
• Subjects: Amyloidosis; Cardiovascular magnetic resonance; Original Research; Survival analysis
• ISSN: 1097-6647; 1532-429X; 1532-429X
• DOI: 10.1016/j.jocmr.2024.101135

Recent evidence underscores the importance of cardiovascular magnetic resonance (CMR) in light chain amyloidosis (AL amyloidosis). We aimed to comprehensively assess the prognostic significance of CMR parametric mapping in AL amyloidosis. This prospective study consecutively included AL amyloidosis patients who underwent CMR imaging before therapy. The statistical analyses included T2, extracellular volume, and native T1 as variates under investigation, adjusted for well-established prognostic markers. The outcome was death from any cause. In total, 195 patients (age, 57.2 ± 9.1 years; male/female, 123/72) were recruited. At the median follow-up time (19 months), the survival probability was approximately 67.2% (131/195). T >44 ms, extracellular volume fraction (ECV) >47%, and native T1 >1468 ms were significantly prognostic (all, P  0.05) in AL amyloidosis. T2 >44 ms was independently prognostic after correcting for left ventricle (LV) late gadolinium enhancement, LV ejection fraction, LV longitudinal strain, and therapeutic response (all, P 44 ms (hazard ratios [HR] 6.611, 95% confidence interval [CI] 1.723–25.361, P = 0.006) was significantly prognostic for mortality after adjustment for cardiac response. Accordingly, T2 >44 ms was significantly associated with mortality (HR 5.734, 95% CI 1.189–27.656, P = 0.030) and remained independently prognostic after correcting for LV late gadolinium enhancement and LV longitudinal strain (both, P