“Dancing Eye Syndrome” Secondary to Opsoclonus-Myoclonus Syndrome in Small-Cell Lung Cancer

Among paraneoplastic neurologic disorders (PND), opsoclonus-myoclonus syndrome, so-called “dancing eye syndrome,” is a rare disorder combining multivectorial eye movements, involuntary multifocal myoclonus, and cerebellar ataxia. Although several paraneoplastic antibodies against postsynaptic or cel...

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Bibliographic Details
Published in:Case reports in medicine 2014-01, Vol.2014 (2014), p.1-4
Main Authors: Elharrar, Xavier, Laroumagne, S., Coiffard, B., Plojoux, J., Dutau, H., Breen, D., Astoul, P.
Format: Article
Language:English
Subjects:
Care and treatment
Case Report
Case studies
Complications and side effects
Diagnosis
Lung cancer
Opsoclonus myoclonus syndrome
Risk factors
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Summary:Among paraneoplastic neurologic disorders (PND), opsoclonus-myoclonus syndrome, so-called “dancing eye syndrome,” is a rare disorder combining multivectorial eye movements, involuntary multifocal myoclonus, and cerebellar ataxia. Although several paraneoplastic antibodies against postsynaptic or cell-surface antigens have been reported, usually most patients are serum antibody negative. We report a 65-year-old patient with opsoclonus-myoclonus syndrome revealing a small-cell lung carcinoma. If serologic antineuronal anti-body screening was negative, autoantibodies against glutamic acid decarboxylase (anti-GAD) were positive. Despite the specific anticancer treatment and high dose corticosteroids, the patient developed a severe and progressive encephalopathy and died 10 days later.
ISSN:1687-9627
1687-9635
DOI:10.1155/2014/545490