Atypical resting-state functional brain connectivity in children with developmental coordination disorder

• Published in: NeuroImage clinical 2022-01, Vol.33, p.102928, Article 102928
• Main Authors: Van Dyck, Dorine, Deconinck, Nicolas, Aeby, Alec, Baijot, Simon, Coquelet, Nicolas, Trotta, Nicola, Rovai, Antonin, Goldman, Serge, Urbain, Charline, Wens, Vincent, De Tiège, Xavier
• Format: Article
• Language: English
• Subjects: Child; Children; Connectome; Developmental coordination disorder; Humans; Magnetoencephalography; Motor disorder; Motor Skills; Motor Skills Disorders - diagnostic imaging; Regular; Resting-state functional connectivity; Sensorimotor Cortex
• ISSN: 2213-1582; 2213-1582
• DOI: 10.1016/j.nicl.2021.102928

•Atypical connectivity in children with developmental coordination disorder.•Stronger connectivity mainly found within the dorsal extrastriate network.•May reflect a brain trait of children with developmental coordination disorder.•This atypical connectivity is not associated with motor/visual perceptual abilities.•Lower visuomotor performance associated with stronger sensorimotor connectivity. Children with developmental coordination disorder (DCD) present lower abilities to acquire and execute coordinated motor skills. DCD is frequently associated with visual perceptual (with or without motor component) impairments. This magnetoencephalography (MEG) study compares the brain resting-state functional connectivity (rsFC) and spectral power of children with and without DCD. 29 children with DCD and 28 typically developing (TD) peers underwent 2 × 5 min of resting-state MEG. Band-limited power envelope correlation and spectral power were compared between groups using a functional connectome of 59 nodes from eight resting-state networks. Correlation coefficients were calculated between fine and gross motor activity, visual perceptual and visuomotor abilities measures on the one hand, and brain rsFC and spectral power on the other hand. Nonparametric statistics were used. Significantly higher rsFC between nodes of the visual, attentional, frontoparietal, default-mode and cerebellar networks was observed in the alpha (maximum statistics, p = .0012) and the low beta (p = .0002) bands in children with DCD compared to TD peers. Lower visuomotor performance (copying figures) was associated with stronger interhemispheric rsFC within sensorimotor areas and power in the cerebellum (right lobule VIII). Children with DCD showed increased rsFC mainly in the dorsal extrastriate visual brain system and the cerebellum. However, this increase was not associated with their coordinated motor/visual perceptual abilities. This enhanced functional brain connectivity could thus reflect a characteristic brain trait of children with DCD compared to their TD peers. Moreover, an interhemispheric compensatory process might be at play to perform visuomotor task within the normative range.