Seroprevalence of varicella-zoster virus antibody and immunogenicity of live attenuated varicella vaccine in healthcare workers in Taiwan

Healthcare workers (HCWs) without evidence of immunity to varicella-zoster virus (VZV) are recommended to undergo varicella vaccination. Immunogenicity of live attenuated varicella vaccine has rarely been investigated among HCWs in Taiwan. Anti-VZV immunoglobulin G (IgG) titer was checked for all HC...

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Published in:Journal of microbiology, immunology and infection immunology and infection, 2023-04, Vol.56 (2), p.274-281
Main Authors: Chong, Chen Hui, Liu, Chun-Eng, Leong, Yin-Yee, Liao, Siang-Ying, Lai, Huei-Wen, Lee, Yu-Lin
Format: Article
Language:English
Subjects:
Antibodies, Viral
Chickenpox
Chickenpox Vaccine
Health Personnel
Herpesvirus 3, Human
Humans
Immunoglobulin G
Nosocomial infection
Seroconversion
Seroepidemiologic Studies
Seroresponse
Seroreversion
Taiwan - epidemiology
Vaccination
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Summary:Healthcare workers (HCWs) without evidence of immunity to varicella-zoster virus (VZV) are recommended to undergo varicella vaccination. Immunogenicity of live attenuated varicella vaccine has rarely been investigated among HCWs in Taiwan. Anti-VZV immunoglobulin G (IgG) titer was checked for all HCWs at Changhua Christian Hospital from 2011 to 2017. One-dose and two-dose (separated by 4–8 weeks) vaccines were administered to HCWs with equivocal and negative anti-varicella IgG results, respectively. Follow-up anti-VZV IgG was determined at least 4 weeks after completion of vaccination. Factors associated with seroconversion to varicella vaccination were analyzed. Among 2406 included HCWs, the anti-VZV IgG serostatus was tested positive, equivocal and negative in 1924 (79.9%), 117 (4.9%) and 365 (15.2%), respectively. The seroprevalence had decreased from 88.0% (235/267) in 2011 to 72.2% (270/374) in 2017 (p for trend
ISSN:1684-1182
1995-9133
DOI:10.1016/j.jmii.2022.09.005