Association of Sleep Characteristics With Nocturnal Hypertension and Nondipping Blood Pressure in the CARDIA Study

• Published in: Journal of the American Heart Association 2020-04, Vol.9 (7), p.e015062-e015062
• Main Authors: Thomas, S Justin, Booth, 3rd, John N, Jaeger, Byron C, Hubbard, Demetria, Sakhuja, Swati, Abdalla, Marwah, Lloyd-Jones, Donald M, Buysse, Daniel J, Lewis, Core E, Shikany, James M, Schwartz, Joseph E, Shimbo, Daichi, Calhoun, David, Muntner, Paul, Carnethon, Mercedes R
• Format: Article
• Language: English
• Subjects: African Americans; ambulatory blood pressure monitoring; Blood Pressure; Circadian Rhythm; Female; Humans; Hypertension - diagnosis; Hypertension - ethnology; Hypertension - physiopathology; Male; Middle Aged; nocturnal hypertension; nondipping systolic blood pressure; obstructive sleep apnea; Original Research; Prevalence; Race Factors; Risk Assessment; Risk Factors; Sleep; Sleep Apnea, Obstructive - diagnosis; Sleep Apnea, Obstructive - ethnology; Sleep Apnea, Obstructive - physiopathology; sleep quality; Time Factors; United States - epidemiology; Whites
• ISSN: 2047-9980; 2047-9980
• DOI: 10.1161/JAHA.119.015062

Background Sleep characteristics and disorders are associated with higher blood pressure (BP) when measured in the clinic setting. Methods and Results We tested whether self-reported sleep characteristics and likelihood of obstructive sleep apnea (OSA) were associated with nocturnal hypertension and nondipping systolic BP (SBP) among participants in the CARDIA (Coronary Artery Risk Development in Young Adults) study who completed 24-hour ambulatory BP monitoring during the year 30 examination. Likelihood of OSA was determined using the STOP-Bang questionnaire. Global sleep quality, habitual sleep duration, sleep efficiency, and midsleep time were obtained from the Pittsburgh Sleep Quality Index. Nocturnal hypertension was defined as mean asleep SBP ≥120 mm Hg or diastolic BP ≥70 mm Hg. Nondipping SBP was defined as a decline in awake-to-asleep SBP