Invasive meningococcal capsular group Y disease, England and Wales, 2007-2009

Enhanced national surveillance for invasive meningococcal disease in England and Wales identified an increase in laboratory-confirmed capsular group Y (MenY) disease from 34 cases in 2007 to 44 in 2008 and 65 in 2009. For cases diagnosed in 2009, patient median age at disease onset was 60 years; 39%...

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Bibliographic Details
Published in:Emerging infectious diseases 2012-01, Vol.18 (1), p.63-70
Main Authors: Ladhani, Shamez N, Lucidarme, Jay, Newbold, Lynne S, Gray, Stephen J, Carr, Anthony D, Findlow, Jamie, Ramsay, Mary E, Kaczmarski, Edward B, Borrow, Raymond
Format: Article
Language:English
Subjects:
Acyltransferases - genetics
Acyltransferases - metabolism
Adolescent
Adult
Age Distribution
Aged
Aged, 80 and over
Bacterial Proteins - genetics
Bacterial Proteins - metabolism
capsular group Y
Care and treatment
Child
Child, Preschool
Diagnosis
DNA sequencing
England - epidemiology
Gene Expression Regulation, Bacterial
Genetic aspects
Humans
Infant
Infant, Newborn
lpxL1
Meningococcal
Meningococcal infections
Meningococcal Infections - epidemiology
Meningococcal Infections - microbiology
Methods
Middle Aged
Mutation
NadA
Neisseria meningitidis, Serogroup Y - classification
Neisseria meningitidis, Serogroup Y - isolation & purification
Nucleic acids
Nucleotide sequencing
outcome
Population Surveillance
Separation
Time Factors
vaccine
Wales - epidemiology
Young Adult
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Summary:Enhanced national surveillance for invasive meningococcal disease in England and Wales identified an increase in laboratory-confirmed capsular group Y (MenY) disease from 34 cases in 2007 to 44 in 2008 and 65 in 2009. For cases diagnosed in 2009, patient median age at disease onset was 60 years; 39% of patients had underlying medical conditions, and 19% died. MenY isolates causing invasive disease during 2007-2009 belonged mainly to 1 of 4 clonal complexes (cc), cc23 (56% of isolates), cc174 (21%), cc167 (11%), and cc22 (8%). The 2009 increase resulted primarily from sequence type 1655 (cc23) (22 cases in 2009, compared with 4 cases each in 2007 and 2008). cc23 was associated with lpxL1 mutations and meningitis in younger age groups (65 years). The increase in MenY disease requires careful epidemiologic and molecular monitoring.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid1801.110901