Clinical presentations and antimicrobial susceptibilities of Corynebacterium cystitidis associated with renal disease in four beef cattle

Background Renal disease caused by Corynebacterium cystitidis in beef cattle may be misclassified as Corynebacterium renale, and limited information about C. cystitidis infections in beef cattle currently is available. Objective To describe clinical presentation, diagnosis, minimum inhibitory concen...

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Bibliographic Details
Published in:Journal of veterinary internal medicine 2020-09, Vol.34 (5), p.2169-2174
Main Authors: Smith, Joe S., Krull, Adam C., Schleining, Jennifer A., Derscheid, Rachel J., Kreuder, Amanda J.
Format: Article
Language:English
Subjects:
Anorexia
Antibiotics
Antimicrobial agents
Beef cattle
Biochemistry
Bladder
Case Report
Corynebacterium cystitidis
Creatinine
Density
Fluids
FOOD AND FIBER ANIMAL
Histopathology
Kidney diseases
Laboratories
Leukopenia
Lymphocytes
Medical records
Neutrophils
Pathogens
Plasma
pyelonephritis
renal
Small intestine
Surgery
Ultrasonic imaging
Urinalysis
urinary
Urine
Veterinarians
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Summary:Background Renal disease caused by Corynebacterium cystitidis in beef cattle may be misclassified as Corynebacterium renale, and limited information about C. cystitidis infections in beef cattle currently is available. Objective To describe clinical presentation, diagnosis, minimum inhibitory concentrations (MICs), and outcome of renal disease caused by C. cystitidis in beef cattle. Methods Retrospective case series. Animals Four client‐owned beef cattle. Results All affected cattle had anorexia as a primary complaint. Of the 3 that had ante‐mortem diagnostic tests performed, all had pyelonephritis based on azotemia in combination with urinalysis and ultrasonographic findings. Cultures yielded C. cystitidis which was identified by biochemical testing, 16S RNA sequencing, and mass spectrometry. All affected cattle deteriorated despite aggressive treatment, indicating that C. cystitidis infections in beef cattle may carry a poor prognosis. Bacterial isolates collected from the 4 cattle showed similarities in MICs for ampicillin, florfenicol, gentamicin, neomycin, sulfadimethoxine, trimethoprim sulfonamide, and tylosin. Conclusions and clinical importance Corynebacterium cystitidis should be considered in the differential diagnosis of cattle with renal disease. Definitive diagnosis of C. cystitidis as compared to C. renale may be challenging.
ISSN:0891-6640
1939-1676
DOI:10.1111/jvim.15844