Comparative analysis of paraclinical parameters in the assessment of osteoporosis: an integrative approach

Osteoporosis is the most common metabolic bone disease with serious physical, psychosocial and economic consequences. It is a chronic, asymptomatic, progressive disease with multifactorial aetiology, characterized by reduced bone mineral density and microarchitectural deterioration of bone tissue; A...

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Bibliographic Details
Published in:Balneo and PRM Research Journal (Online. English ed.) 2025-12, Vol.15 (4), p.756
Main Authors: Oana Raluca Antonescu, Sinziana Calina Silisteanu, Alina Cristiana Venter, Mihaela Racheriu, Irina Elena Antonescu, Enikő Nemes-Nagy
Format: Article
Language:English
Subjects:
biomarkers
osteoporosis
postmenopausal women
screening
Online Access:Get full text
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Summary:Osteoporosis is the most common metabolic bone disease with serious physical, psychosocial and economic consequences. It is a chronic, asymptomatic, progressive disease with multifactorial aetiology, characterized by reduced bone mineral density and microarchitectural deterioration of bone tissue; A retrospective study was conducted, which included an initial cohort of 243 patients hospitalized between January 2023 and December 2023 at the County Emergency Hospital of Sibiu, Clinical Endocrinology Department ; Study results suggest that assessment of bone mineral density (BMD) remains a primary standard in the diagnosis of osteoporosis, as measured by T and Z scores from DXA densitometry. However, biomarkers such as total calcium, ionic calcium, vitamin D, phosphorus, PTH and bone degradation markers (e.g. Beta Crosslaps) play a significant role in assessing bone metabolism and identifying fracture risk; The study highlights the importance of screening in postmenopausal women and the need for calcium and vitamin D supplementation in patients with osteoporosis or osteopenia
ISSN:2734-8458
DOI:10.12680/balneo.2024.756