Should androgen deprivation therapy and other systemic treatments be used in men with prostate cancer and a rising PSA post-local treatments?

Biochemical recurrence is an evolving space in prostate cancer, with increasing multidisciplinary involvement. Androgen deprivation therapy has shown proof of its value in complementing salvage radiotherapy in high-risk biochemical relapsing patients; ongoing trials aim to further refine this treatm...

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Bibliographic Details
Published in:Therapeutic Advances in Medical Oncology 2021, Vol.13, p.17588359211051870-17588359211051870
Main Authors: Patrikidou, Anna, Zilli, Thomas, Baciarello, Giulia, Terisse, Safae, Hamilou, Zineb, Fizazi, Karim
Format: Article
Language:English
Subjects:
Androgen receptors
Androgens
Biopsy
Clinical trials
Metastases
Patients
Precision medicine
Prostate cancer
Radiation therapy
Review
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Summary:Biochemical recurrence is an evolving space in prostate cancer, with increasing multidisciplinary involvement. Androgen deprivation therapy has shown proof of its value in complementing salvage radiotherapy in high-risk biochemical relapsing patients; ongoing trials aim to further refine this treatment combination. As systemic treatments, and notably next-generation androgen receptor targeted agents, have moved towards early hormone-sensitive and non-metastatic stages, the prostate specific antigen (PSA)-relapse disease stage will be undoubtedly challenged by future evidence from such ongoing clinical trials. With the use of modern imaging and newer molecular technologies, including integration of tumoral genomic profiling and liquid biopsies in risk stratification, a path towards a precision oncology-focused approach will become a reality to guide in the future decisions for patients with a diagnosis of biochemical recurrence.
ISSN:1758-8359
1758-8340
1758-8359
DOI:10.1177/17588359211051870