Wound Healing, Antimicrobial and Antioxidant Properties of Clinacanthus nutans (Burm.f.) Lindau and Strobilanthes crispus (L.) Blume Extracts

• Published in: Molecules (Basel, Switzerland) Switzerland), 2022-03, Vol.27 (5), p.1722
• Main Authors: Ban, Weng Kit, Fong, Isabel Lim, Khong, Heng Yen, Phung, Joyce Hui Yie
• Format: Article
• Language: English
• Subjects: Acanthaceae - chemistry; Acetone; Agar; Anti-Bacterial Agents - pharmacology; Anti-Infective Agents - pharmacology; Antibiotics; Antidiabetics; Antidiuretics; Antiinfectives and antibacterials; Antimicrobial agents; Antioxidants; Antioxidants - chemistry; Antioxidants - pharmacology; Assaying; Bacteria; Chloroform; Clinacanthus nutans; Diabetes mellitus; Drug resistance; Ethanol; Fibroblasts; Flavonoids; Gram-Negative Bacteria; Gram-Positive Bacteria; Herbal medicine; Methicillin; Methicillin-Resistant Staphylococcus aureus; Phenolic compounds; Phenols; Plant Extracts - chemistry; Plant Extracts - pharmacology; Pseudomonas aeruginosa; scratch assay; Skin; Skin resistance; Staphylococcus aureus; Staphylococcus infections; Strobilanthes crispus; Wound Healing
• ISSN: 1420-3049; 1420-3049
• DOI: 10.3390/molecules27051722

is known to be an anticancer and antiviral agent, and has proven to be an antidiuretic and antidiabetic agent. However, there is a high possibility that these plants possess multiple beneficial properties, such as antimicrobial and wound healing properties. This study aims to assess the wound healing, antioxidant, and antimicrobial properties of and . The and leaves were dried, ground, and extracted with ethanol, acetone, and chloroform through cold maceration. In a modified scratch assay with co-incubation of skin fibroblast and Methicillin-resistant , and extracts were assessed for their wound healing potential, and the antimicrobial activities of and extracts were performed on a panel of Gram-positive and Gram-negative bacteria on Mueller-Hinton agar based on a disc diffusion assay. To assess for antioxidant potential, 2,2-diphenyl-1-picrylhydrazyl (DPPH), total phenolic and total flavonoid assays were conducted. In the modified scratch assay, extracts aided in the wound healing activity while in the presence of MRSA, and extracts were superior in antimicrobial and wound healing activities. In addition, extracts were superior to extracts against on Mueller-Hinton agar. Acetone-extracted contained the highest level of antioxidant in comparison with other extracts.