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JAK2V617F variant allele frequency >50% identifies patients with polycythemia vera at high risk for venous thrombosis
Arterial (AT) and venous (VT) thrombotic events are the most common complications in patients with polycythemia vera (PV) and are the leading causes of morbidity and mortality. In this regard, the impact of JAK2 V617F variant allele frequency (VAF) is still debated. The purpose of the current study...
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Published in: | Blood cancer journal (New York) 2021-12, Vol.11 (12), p.199-199, Article 199 |
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Main Authors: | , , , , , , , , , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Arterial (AT) and venous (VT) thrombotic events are the most common complications in patients with polycythemia vera (PV) and are the leading causes of morbidity and mortality. In this regard, the impact of
JAK2
V617F variant allele frequency (VAF) is still debated. The purpose of the current study was to analyze the impact of
JAK2
V617F VAF in the context of other established risk factors for thrombosis in a total of 865 2016 WHO-defined PV patients utilizing two independent cohorts: University of Florence (
n
= 576) as a training cohort and Policlinico Gemelli, Catholic University, Rome (
n
= 289) as a validation cohort. In the training cohort VT free-survival was significantly shorter in the presence of a
JAK2
V617F VAF > 50% (HR 4;
p
50% (HR 3.8,
p
= 0.001) and previous VT (HR 2.2;
p
= 0.04) as independent risk factors for future VT whereas diabetes (HR 2.4;
p
= 0.02), hyperlipidemia (HR 2.3;
p
= 0.01) and previous AT (HR 2;
p
= 0.04) were independent risk factors for future AT. Similarly,
JAK2
V617F VAF > 50% (HR 2.4;
p
= 0.01) and previous VT (HR 2.8;
p
= 0.005) were confirmed as independent predictors of future VT in the validation cohort. Impact of
JAK2
V617F VAF > 50% on VT was particularly significant in conventional low-risk patients, both in Florence (HR 10.6,
p
= 0.005) and Rome cohort (HR 4;
p
= 0.02). In conclusion, we identified
JAK2
V617F VAF > 50% as an independent strong predictor of VT, supporting that AT and VT are different entities which might require distinct management. |
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ISSN: | 2044-5385 2044-5385 |
DOI: | 10.1038/s41408-021-00581-6 |