Functional connectivity fingerprints of the human pulvinar: Decoding its role in cognition

• Published in: NeuroImage (Orlando, Fla.) Fla.), 2020-11, Vol.221, p.117162-117162, Article 117162
• Main Authors: Guedj, Carole, Vuilleumier, Patrik
• Format: Article
• Language: English
• Subjects: Adult; Animal cognition; Attention; Cerebral Cortex - diagnostic imaging; Cerebral Cortex - physiology; Clustering; Cognitive ability; Connectivity; Connectome; Female; Functional morphology; Human remains; Humans; Information processing; Magnetic Resonance Imaging; Male; Meta-analysis; Meta-Analysis as Topic; Monkeys & apes; Nerve Net - diagnostic imaging; Nerve Net - physiology; Neural networks; Parcellation; Perception; Pulvinar; Pulvinar - diagnostic imaging; Pulvinar - physiology; Sensory integration; Systematic review; Thalamo-cortical circuit; Thalamus; Young Adult
• ISSN: 1053-8119; 1095-9572
• DOI: 10.1016/j.neuroimage.2020.117162

The pulvinar is the largest thalamic nucleus in the brain and considered as a key structure in sensory processing and attention. Although its anatomy is well known, in particular thanks to studies in non-human primates, its role in perception and cognition remains poorly understood. Here, we used resting-state functional connectivity from a large sample of high-resolution data provided by the Human Connectome Project, combined with a large-scale meta-analysis approach to segregate and characterize the functional organization of the pulvinar nucleus. We identified five clusters per pulvinar with distinct connectivity profiles and determined their respective co-activation patterns. Using the Neurosynth database, we then investigated the functional significance of these co-activation networks. Our results confirm the functional heterogeneity of the pulvinar, revealing clearcut differences across clusters in terms of their connectivity patterns and associated cognitive domains. While the anterior and lateral clusters appear to be involved in action and attention domains, the ventromedial and dorsomedial clusters may preferentially subserve emotional processes and saliency detection. In contrast, the inferior cluster shows less specificity but correlates with perception and memory processes. Collectively, our results suggest that the pulvinar underwrites different components of cognition, supporting a central role in the coordination of cortico-subcortical processes mediated by distributed brain networks.