Radiomics analysis of contrast-enhanced CT predicts lymphovascular invasion and disease outcome in gastric cancer: a preliminary study

To determine whether radiomics features based on contrast-enhanced CT (CECT) can preoperatively predict lymphovascular invasion (LVI) and clinical outcome in gastric cancer (GC) patients. In total, 160 surgically resected patients were retrospectively analyzed, and seven predictive models were const...

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Bibliographic Details
Published in:Cancer imaging 2020-04, Vol.20 (1), p.24-24, Article 24
Main Authors: Chen, Xiaofeng, Yang, Zhiqi, Yang, Jiada, Liao, Yuting, Pang, Peipei, Fan, Weixiong, Chen, Xiangguang
Format: Article
Language:English
Subjects:
Analysis
Antigens
Artificial intelligence
Cancer
Cancer research
Clinical outcome
Gastric cancer
Histopathology
Inhomogeneity
Lymphovascular invasion
Mortality
Nomograms
Open source software
Patient outcomes
Patients
Prediction models
Prognosis
Radiomics
Rank tests
Regression analysis
Risk analysis
Risk factors
Stomach cancer
Studies
Surgery
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Summary:To determine whether radiomics features based on contrast-enhanced CT (CECT) can preoperatively predict lymphovascular invasion (LVI) and clinical outcome in gastric cancer (GC) patients. In total, 160 surgically resected patients were retrospectively analyzed, and seven predictive models were constructed. Three radiomics predictive models were built from radiomics features based on arterial (A), venous (V) and combination of two phase (A + V) images. Then, three Radscores (A-Radscore, V-Radscore and A + V-Radscore) were obtained. Another four predictive models were constructed by the three Radscores and clinical risk factors through multivariate logistic regression. A nomogram was developed to predict LVI by incorporating A + V-Radscore and clinical risk factors. Kaplan-Meier curve and log-rank test were utilized to analyze the outcome of LVI. Radiomics related to tumor size and intratumoral inhomogeneity were the top-ranked LVI predicting features. The related Radscores showed significant differences according to LVI status (P 
ISSN:1470-7330
1740-5025
1470-7330
DOI:10.1186/s40644-020-00302-5