Earth-friendly-assessed silver-nanoparticles spectrophotometric method for rapid and sensitive analysis of Molnupiravir, an FDA-approved candidate for COVID-19: application on pharmaceutical formulation and dissolution test

Molnupiravir is the first oral direct-acting antiviral prodrug recently approved for the COVID-19 pandemic. Here and for the first time, we present a novel, sensitive, robust, and simple silver-nanoparticles spectrophotometric technique for molnupiravir analysis in its capsules and dissolution media...

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Bibliographic Details
Published in:BMC chemistry 2023-03, Vol.17 (1), p.13-13, Article 13
Main Authors: Mohamed, Ahmed R., Abolmagd, Ebrahim, Nour, Israa M., Badrawy, Mohamed, Hasan, Mohamed A.
Format: Article
Language:English
Subjects:
Absorbance
Antiviral agents
Antiviral drugs
Chemical synthesis
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Chromatography
Coronaviruses
COVID-19
Disease transmission
Dissolution
Dissolution test
Eco-scale
GAPI
Methods
Molnupiravir
Nanoparticles
Oxidation
Oxidizing agents
Polyvinylpyrrolidone
Redox reactions
Reducing agents
Silver
Silver nitrate
Silver-nanoparticles
Spectrophotometry
Stabilizers (agents)
Surface plasmon resonance
Transmission electron microscopes
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Summary:Molnupiravir is the first oral direct-acting antiviral prodrug recently approved for the COVID-19 pandemic. Here and for the first time, we present a novel, sensitive, robust, and simple silver-nanoparticles spectrophotometric technique for molnupiravir analysis in its capsules and dissolution media. This spectrophotometric technique involved silver-nanoparticles synthesis through a redox reaction between the reducing agent (molnupiravir) and the oxidizing agent (silver nitrate) in presence of polyvinylpyrrolidone as a stabilizing agent. The produced silver-nanoparticles have an intense surface plasmon resonance peak at 416 nm where the measured absorbance values were utilized for the quantitative analysis of molnupiravir. The produced silver-nanoparticles were recognized by using the transmission electron microscope. Under optimal conditions, a good linear rapport was accomplished between molnupiravir concentrations and the corresponding absorbance values in a range of (100–2000) ng/mL with a detection limit of 30 ng/mL. Greenness assessment was implemented using eco-scale scoring and GAPI disclosing the excellent greenness of the suggested technique. The suggested silver-nanoparticles technique was authenticated according to recommendations of the ICH and statistically assessed with the reported liquid chromatographic method without significant differences regarding accuracy or precision. Accordingly, the suggested technique is deemed a green and cheap alternative for assaying molnupiravir due to its reliance primarily on water. Furthermore, the suggested technique’s high sensitivity can be employed for investigating molnupiravir bioequivalence in future studies. Graphical Abstract
ISSN:2661-801X
2661-801X
DOI:10.1186/s13065-023-00933-2