Serum isthmin-1 levels are positively and independently correlated with albuminuria in patients with type 2 diabetes mellitus

IntroductionIsthmin-1 (Ism-1), as a novel adipokine, plays a role in glucose homeostasis and lipid metabolism. However, the relationship between Ism-1 and type 2 diabetes mellitus (T2DM) remains unclear. This study aims to investigate the association of serum Ism-1 levels with albuminuria and insuli...

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Published in:BMJ open diabetes research & care 2022-09, Vol.10 (5), p.e002972
Main Authors: Wang, Chuan, Xu, Mingyue, Feng, Ruiying, Zhang, Lei, Yin, Xiaofei, Feng, Ruoqi, Liang, Kai, Liu, Jinbo
Format: Article
Language:English
Subjects:
Adipokines
Alcohol
Body mass index
Cholesterol
Chronic illnesses
Creatinine
Diabetes
Diabetes Mellitus, Type 2
Diabetic retinopathy
Glucose
High density lipoprotein
Homeostasis
Hyperglycemia
Hypertension
Insulin Resistance
Kidney Diseases
Kinases
Metabolism
Pathophysiology/Complications
Peptides
Regression analysis
Smoking
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Summary:IntroductionIsthmin-1 (Ism-1), as a novel adipokine, plays a role in glucose homeostasis and lipid metabolism. However, the relationship between Ism-1 and type 2 diabetes mellitus (T2DM) remains unclear. This study aims to investigate the association of serum Ism-1 levels with albuminuria and insulin resistance in patients with T2DM and preserved renal function.Research design and methodsA total of 150 patients with T2DM were recruited. The presence of albuminuria was evaluated by urinary albumin:creatinine ratio (UACR) in first morning urine sample. Serum Ism-1 levels were tested by ELISA. Homeostasis model assessments were used to evaluate insulin resistance. Binary logistic regression and multivariable linear regression analyses were used to assess the association of serum Ism-1 levels with albuminuria. Multivariable linear regression analyses were performed to explore the correlation of serum Ism-1 levels with insulin resistance.ResultsCompared with the normal-albuminuria and microalbuminuria groups, serum Ism-1 levels were significantly higher in the macroalbuminuria group (p
ISSN:2052-4897
2052-4897
DOI:10.1136/bmjdrc-2022-002972