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ALKBH5 inhibitors as a potential treatment strategy in heart failure—inferences from gene expression profiling
Heart Failure (HF) is a complex clinical syndrome in which the heart is unable to provide enough blood flow to meet metabolic needs and lacks efficient venous return. HF is a major risk factor for morbidity and mortality with cardiovascular diseases globally. Despite enormous research, the molecular...
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Published in: | Frontiers in cardiovascular medicine 2023-07, Vol.10, p.1194311-1194311 |
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Main Authors: | , , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | Heart Failure (HF) is a complex clinical syndrome in which the heart is unable to provide enough blood flow to meet metabolic needs and lacks efficient venous return. HF is a major risk factor for morbidity and mortality with cardiovascular diseases globally. Despite enormous research, the molecular markers relevant to disease prognosis and management remain not well understood. Here, we analyzed the whole transcriptomes of 18 failing hearts and 15 non-failing hearts (predominantly of Caucasian origin), by applying the standard
in silico
tools. The analyses revealed novel gene-markers including
ALKBH5
of mRNA demethylation and
KMT2E
of histone modification processes, significantly over-expressed in the HF compared with the non-failing hearts (FDR |
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ISSN: | 2297-055X 2297-055X |
DOI: | 10.3389/fcvm.2023.1194311 |