Melatonin Improves Outcomes of Heatstroke in Mice by Reducing Brain Inflammation and Oxidative Damage and Multiple Organ Dysfunction

We report here that when untreated mice underwent heat stress, they displayed thermoregulatory deficit (e.g., animals display hypothermia during room temperature exposure), brain (or hypothalamic) inflammation, ischemia, oxidative damage, hypothalamic-pituitary-adrenal axis impairment (e.g., decreas...

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Bibliographic Details
Published in:Mediators of Inflammation 2013-01, Vol.2013 (2013), p.12-19-101
Main Authors: Tian, Yu-Feng, Lin, Cheng-Hsien, Hsu, Shu-Fen, Lin, Mao- Tsun
Format: Article
Language:English
Subjects:
Adrenocorticotropic Hormone - blood
Animals
Antioxidants - therapeutic use
Corticosterone - blood
Disease Models, Animal
Glutathione - metabolism
Glutathione Peroxidase - metabolism
Glutathione Reductase - metabolism
Health aspects
Heat Stroke - physiopathology
Heatstroke
Hot Temperature
Inflammation
Inflammation - drug therapy
Lipid Peroxidation
Male
Melatonin
Melatonin - therapeutic use
Mice
Mice, Inbred ICR
Multiple Organ Failure - drug therapy
Multiple Organ Failure - etiology
Multiple Organ Failure - physiopathology
Oxidative Stress
Oxygen - metabolism
Patient outcomes
Prevention
Temperature
Treatment Outcome
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Summary:We report here that when untreated mice underwent heat stress, they displayed thermoregulatory deficit (e.g., animals display hypothermia during room temperature exposure), brain (or hypothalamic) inflammation, ischemia, oxidative damage, hypothalamic-pituitary-adrenal axis impairment (e.g., decreased plasma levels of both adrenocorticotrophic hormone and corticosterone during heat stress), multiple organ dysfunction or failure, and lethality. Melatonin therapy significantly reduced the thermoregulatory deficit, brain inflammation, ischemia, oxidative damage, hypothalamic-pituitary-adrenal axis impairment, multiple organ dysfunction, and lethality caused by heat stroke. Our data indicate that melatonin may improve outcomes of heat stroke by reducing brain inflammation, oxidative damage, and multiple organ dysfunction.
ISSN:0962-9351
1466-1861
DOI:10.1155/2013/349280