Diet-induced insulin resistance altered cardiac GLUT4 and FATP/CD36 expression in rats

Background Altered substrate transport protein expression is central to the effect of insulin resistance on cardiac metabolism. The present study was thus designed to investigate the comparative effects of high fat, high sucrose and salt-induced IR on cardiac expression of fatty acid transporter (FA...

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Bibliographic Details
Published in:Beni-Suef University journal of basic and applied sciences 2022-12, Vol.11 (1), p.1-8, Article 131
Main Authors: Afolabi, Oladele Ayobami, Alabi, Babatunde Adebola, Oluranti, Olufemi
Format: Article
Language:English
Subjects:
Cardiac metabolism
Energy substrate
Hyperinsulinemia
Medicine
Medicine & Public Health
Substrate utilization
Transport protein
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Summary:Background Altered substrate transport protein expression is central to the effect of insulin resistance on cardiac metabolism. The present study was thus designed to investigate the comparative effects of high fat, high sucrose and salt-induced IR on cardiac expression of fatty acid transporter (FATP) and glucose transporter (GLUT4) in rats. Results Rats fed with high fat, high sucrose and salt diets developed impaired glucose tolerance ( p  > 0.05) and hyperinsulinemia ( p  
ISSN:2314-8543
2314-8543
DOI:10.1186/s43088-022-00312-1