Effects of diabetes on the development of radiation pneumonitis

Radiation pneumonia (RP) is a common adverse reaction to radiation therapy in patients with chest tumors. Recent studies have shown that diabetes mellitus (DM), which can cause systemic multisystem damage, specifically targets lungs, and the incidence of RP in patients with a history of diabetes is...

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Bibliographic Details
Published in:Respiratory research 2021-05, Vol.22 (1), p.160-8, Article 160
Main Authors: Dong, Guangtong, Li, Yuxiao, Zhao, Qiyao, Pang, Bing, Qi, Xin, Wei, Junping, Hou, Wei
Format: Article
Language:English
Subjects:
Animals
Bacterial pneumonia
Cancer therapies
Clinical aspects
Complications and side effects
Cytokines
Diabetes
Diabetes mellitus
Diabetes Mellitus - epidemiology
Diabetes Mellitus - immunology
Diabetes Mellitus - metabolism
Disease
Glucose
Humans
Hyperglycemia
Incidence
Inflammation
Inflammation Mediators - metabolism
Inflammatory diseases
Influence factors
Insulin resistance
Lung cancer
Metabolism
Metabolites
Neoplasms - epidemiology
Neoplasms - radiotherapy
Oxidative Stress
Pneumonia
Pneumonitis
Prognosis
Radiation injuries
Radiation pneumonia
Radiation Pneumonitis - epidemiology
Radiation Pneumonitis - immunology
Radiation Pneumonitis - metabolism
Radiation therapy
Radiotherapy
Reactive Oxygen Species - metabolism
Review
Risk analysis
Risk Assessment
Risk Factors
Tumor necrosis factor-TNF
Tumors
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Description
Summary:Radiation pneumonia (RP) is a common adverse reaction to radiation therapy in patients with chest tumors. Recent studies have shown that diabetes mellitus (DM), which can cause systemic multisystem damage, specifically targets lungs, and the incidence of RP in patients with a history of diabetes is higher than that in other patients with tumors who have undergone radiotherapy. DM is an important risk factor for RP in tumor patients undergoing RT, and patients with DM should be treated with caution. This article reviews research on the clinical aspects, as well as the mechanism, of the effects of diabetes on RP and suggests future research needed to reduce RP.
ISSN:1465-993X
1465-9921
1465-993X
1465-9921
DOI:10.1186/s12931-021-01754-4