Retrospective Analysis of Epidemiology, Risk Factors, and Outcomes of Health Care-Acquired Carbapenem-Resistant Klebsiella pneumoniae Bacteremia in a Chinese Tertiary Hospital, 2010–2019

• Published in: Infectious diseases and therapy 2023-02, Vol.12 (2), p.473-485
• Main Authors: Li, Meng, Yang, Shanshan, Yao, Hongwu, Liu, Yunxi, Du, Mingmei
• Format: Article
• Language: English
• Subjects: Antibiotics; Carbapenem-resistant Klebsiella pneumoniae; Catheters; Epidemiology; Health aspects; Health care; Hospitals; Imipenem; Infectious Diseases; Internal Medicine; Medical instruments; Medicine; Medicine & Public Health; Mortality; Original Research; Pancreatitis; Regression analysis; Resistance rate; Respiratory diseases; Respiratory tract diseases; Risk factors; Ventilation; Ventilators
• ISSN: 2193-8229; 2193-6382
• DOI: 10.1007/s40121-022-00732-7

Introduction In the present study, we aimed to describe the proportion of carbapenem-resistant Klebsiella pneumoniae bloodstream infection (CRKP-BSI) in KP-BSI in one Chinese tertiary hospital over 10 years and determine the risk factors and outcomes of CRKP-BSI. Methods We retrospectively analyzed clinical and microbiological data of patients with KP-BSI from January 2010 to December 2019 to identify risk factors, clinical features, and outcomes using multivariate logistic regression analysis. KP-BSI only included monomicrobial BSI and health care-acquired BSI. Results Among the total 687 isolates of KP-BSI in this study, the rate of CRKP was 39.0% (268/687); this rate in the intensive care unit (ICU) was 65.6% and that in seven high-risk departments (including four ICUs, respiratory medicine, gastroenterology medicine, and hepatobiliary surgery) was 74.6%. The annual rate of CRKP in KP-BSI ranged from 0.0% in 2010 to 54.5% in 2019. The 28-day mortality was 36.2% in patients with CRKP-BSI and 11.7% in those with carbapenem-susceptible K. pneumoniae (CSKP) BSI. Multivariable logistic regression analysis showed that prior ICU stay (odds ratio [OR] 2.485, P