Effects of Metal Welding Fumes on Kidney Function Parameters in Male Albino Rats

Welding is described as one of the most hazardous occupations. The study aims to determine the influence of metal welding fumes on kidney function parameters in blood of the exposed animals. The fumes were collected from welding sites during the activity by a skilled welder. One hundred thirty exper...

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Bibliographic Details
Published in:Athens Journal of Health and Medical Sciences 2020-06, Vol.7 (2), p.63-74
Main Authors: Lawal Abdullahi, Ibrahim, Sani, Ali
Format: Article
Language:English
Subjects:
effects
evaluation
kidney function
metal welding fumes
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Summary:Welding is described as one of the most hazardous occupations. The study aims to determine the influence of metal welding fumes on kidney function parameters in blood of the exposed animals. The fumes were collected from welding sites during the activity by a skilled welder. One hundred thirty experimental animals were used and made into 13 groups. Twelve groups were given dosages calculated to correspond to real life workers exposure regimes and 1 group served as control. The dosages were administered intratracheally after been anesthetized weekly for 12 weeks. The animals were sacrificed and whole blood samples were taken. Serum was used to determine urea, chloride (Cl), Sodium (Na), Potassium (K) and the activity of creatinkinase (CK). The values of Urea and Creatinine in the treatment groups have exceeded the control values and slightly significant. Values of electrolytes Cl, K and Na in all the treatment groups have exceeded the control. Thus, it shows impairment of the kidney by elevated serum levels of the metabolites and probable damage in the kidney function. Benchmark dose and standard limits should be proposed for such occupations in Kano.
ISSN:2653-9411
2653-9411
DOI:10.30958/ajhms.7-2-1