Core-Shell Nanofibrous Scaffold Based on Polycaprolactone-Silk Fibroin Emulsion Electrospinning for Tissue Engineering Applications

The vast domain of regenerative medicine comprises complex interactions between specific cells' extracellular matrix (ECM) towards intracellular matrix formation, its secretion, and modulation of tissue as a whole. In this domain, engineering scaffold utilizing biomaterials along with cells tow...

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Bibliographic Details
Published in:Bioengineering (Basel) 2018-08, Vol.5 (3), p.68
Main Authors: Roy, Trina, Maity, Priti Prasanna, Rameshbabu, Arun Prabhu, Das, Bodhisatwa, John, Athira, Dutta, Abir, Ghorai, Sanjoy Kumar, Chattopadhyay, Santanu, Dhara, Santanu
Format: Article
Language:English
Subjects:
amphiphilic
Binding sites
Biocompatibility
Biodegradability
Bioengineering
Biological activity
Biomaterials
Biomedical materials
Biopolymers
Cellular structure
Collagen
Contact angle
Core-shell structure
Electrospinning
emulsion
Emulsion polymerization
Extracellular matrix
Growth factors
hydrophilicity
Materials selection
Molecular weight
Nanofibers
Polycaprolactone
Polymer blends
Proteins
Regeneration (physiology)
Regenerative medicine
Scaffolds
Secretion
Silk
Silk fibroin
Tissue engineering
Viscosity
Wound healing
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Summary:The vast domain of regenerative medicine comprises complex interactions between specific cells' extracellular matrix (ECM) towards intracellular matrix formation, its secretion, and modulation of tissue as a whole. In this domain, engineering scaffold utilizing biomaterials along with cells towards formation of living tissues is of immense importance especially for bridging the existing gap of late; nanostructures are offering promising capability of mechano-biological response needed for tissue regeneration. Materials are selected for scaffold fabrication by considering both the mechanical integrity and bioactivity cues they offer. Herein, polycaprolactone (PCL) (biodegradable polyester) and 'nature's wonder' biopolymer silk fibroin (SF) are explored in judicious combinations of emulsion electrospinning rather than conventional electrospinning of polymer blends. The water in oil (W/O) emulsions' stability is found to be dependent upon the concentration of SF (aqueous phase) dispersed in the PCL solution (organic continuous phase). The spinnability of the emulsions is more dependent upon the viscosity of the solution, dominated by the molecular weight of PCL and its concentration than the conductivity. The nanofibers exhibited distinct core-shell structure with better cytocompatibility and cellular growth with the incorporation of the silk fibroin biopolymer.
ISSN:2306-5354
2306-5354
DOI:10.3390/bioengineering5030068