Association between fractional amplitude of low-frequency fluctuation (fALFF) and facial emotion recognition ability in first-episode schizophrenia patients: a fMRI study

It was still unclear that the correlation between the resting-state intrinsic activity in brain regions and facial emotion recognition (FER) ability in patients with first-episode schizophrenia (FSZ). Our aim was to analyse the correlation between the fractional amplitude of low-frequency fluctuatio...

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Bibliographic Details
Published in:Scientific reports 2022-11, Vol.12 (1), p.19561-8, Article 19561
Main Authors: Kuang, Qijie, Zhou, Sumiao, Li, Haijing, Mi, Lin, Zheng, Yingjun, She, Shenglin
Format: Article
Language:English
Subjects:
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Amygdala
Brain
Brain Mapping
Correlation analysis
Facial Recognition
Functional magnetic resonance imaging
Humanities and Social Sciences
Humans
Magnetic Resonance Imaging - methods
Mental disorders
Meta-analysis
multidisciplinary
Pattern recognition
Schizophrenia
Schizophrenia - diagnostic imaging
Science
Science (multidisciplinary)
Supplementary motor area
Visual perception
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Summary:It was still unclear that the correlation between the resting-state intrinsic activity in brain regions and facial emotion recognition (FER) ability in patients with first-episode schizophrenia (FSZ). Our aim was to analyse the correlation between the fractional amplitude of low-frequency fluctuation (fALFF) and FER ability in FSZ patients. A total of 28 patients with FSZ and 33 healthy controls (HCs) completed visual search tasks for FER ability. Regions of interest (ROIs) related to facial emotion were obtained from a previous meta-analysis. Pearson correlation analysis was performed to understand the correlation between fALFF and FER ability. Our results indicated that the patients performed worse than the HCs in the accuracy performances of happy FER and fearful FER. The previous meta-analysis results showed that the brain regions related to FER included the bilateral amygdala (AMY)/hippocampus (HIP), right fusiform gyrus (FFG), and right supplementary motor area (SMA). Partial correlation analysis showed that the fALFF of the right FFG was associated with high-load fearful FER accuracy (r = − 0.60, p  = 0.004). Our study indicated that FER ability is correlated with resting-state intrinsic activity in brain regions related to facial emotion, which may provide a reference for the study of FER deficiency in schizophrenia.
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-022-24258-7